1. Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson, Michael Maxwell, Jennifer Davies, Adhithya Sankar, Elaine Boland, Rajiv Gandhi, Irene Tracey, and Solomon Tesfaye Diabetes Care Volume 37: 1681-1688 June, 2014

2. STUDY OBJECTIVE To investigate any differences in brain structure in subjects with diabetic peripheral neuropathy (DPN) Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688

3. STUDY DESIGN AND METHODS 36 subjects with type 1 diabetes underwent neurophysiological assessment to quantify the severity of DPN: No DPN, n = 18 Painful DPN, n = 9 Painless DPN, n = 9 All subjects underwent volumetric brain magnetic resonance imaging at 3 Tesla Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688

4. RESULTS Adjusted peripheral gray matter volume was statistically significantly lower in subjects with painless and painful DPN than in subjects with no DPN and healthy volunteers (HVs) Difference was not statistically significant in adjusted peripheral gray matter volume between subjects with no DPN and HVs and those with painful DPN and painless DPN Voxel-based morphometry analyses revealed greater localized volume loss in the primary somatosensory cortex, supramarginal gyrus, and cingulate cortex in DPN subjects Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688

7. CONCLUSIONS There is increased peripheral gray matter volume loss localized to regions involved with somatosensory perception in subjects with DPN This finding may have important implications for the long- term prognosis of DPN Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688