1. The Effect of a Diabetes-Specific Cognitive Behavioral Treatment Program (DIAMOS) for Patients With Diabetes and Subclinical Depression: Results of a Randomized Controlled Trial Featured Article: Norbert Hermanns, Andreas Schmitt, Annika Gahr, Christian Herder, Bettina Nowotny, Michael Roden, Christian Ohmann, Johannes Kruse, Thomas Haak, and Bernhard Kulzer Diabetes Care Volume 38: 551-560 April, 2015

2. STUDY OBJECTIVE Subclinical depression is associated with a poorer long-term prognosis in diabetes Because of the lack of specific intervention concepts, DIAMOS was newly developed and evaluated in a randomized trial Hermanns N. et al. Diabetes Care 2015;38:551-560

3. STUDY DESIGN AND METHODS DIAMOS is composed of cognitive behavioral interventions to reduce diabetes distress The active control group received diabetes education The primary outcome was depressive symptoms Secondary outcomes were: Diabetes distress Well-being Self-care behavior Diabetes acceptance Diabetes treatment satisfaction HbA1c Subclinical inflammation Hermanns N. et al. Diabetes Care 2015;38:551-560

4. RESULTS 214 participants were randomized 2-month follow-up revealed a stronger reduction of depressive symptoms in the DIAMOS group than in the control group The Patient Health Questionnaire-9 and Diabetes Distress Scale scores displayed significant treatment effects Risk of incident major depression in the DIAMOS group was significantly reduced Inflammatory variables were not substantially affected Hermanns N. et al. Diabetes Care 2015;38:551-560

6. CONCLUSIONS DIAMOS effectively lowers depressive symptoms and diabetes- related distress in patients with subclinical depression DIAMOS helps to prevent the incidence of major depression Hermanns N. et al. Diabetes Care 2015;38:551-560