1. Brain Atrophy in Type 2 Diabetes Regional distribution and influence on cognition Featured Article: Chris Moran, M.B., B.C.H., Thanh G. Phan, P.H.D., Jian Chen, M.E., Leigh Blizzard, P.H.D., Richard Beare, P.H.D, Alison Venn, P.H.D., Gerald Münch, P.H.D., Amanda G. Wood, P.H.D., Josephine Forbes, P.H.D., Timothy M. Greenaway, P.H.D., Susan Pearson, P.H.D., Velandai Srikanth, P.H.D. Diabetes Care Volume 36: 4036-4042 December, 2013

2. STUDY OBJECTIVE Type 2 diabetes (T2DM) is associated with brain atrophy and cerebrovascular disease We define the regional distribution of brain atrophy in T2DM and examine if atrophy or cerebrovascular lesions are links between T2DM and cognitive function Moran C. et al. Diabetes Care 2013;36:4036-4042

3. STUDY DESIGN AND METHODS Magnetic resonance imaging (MRI) scans and cognitive tests were used in 350 participants with T2DM and 363 participants without T2DM With voxel-based morphometry, regional distribution of atrophy in T2DM was studied Cerebrovascular lesions and atrophy were measured while blinded to T2DM status Moran C. et al. Diabetes Care 2013;36:4036-4042

4. RESULTS T2DM was associated with more cerebral infarcts and lower total gray, white, and hippocampal volumes but not with microbleeds or white matter hyperintensity T2DM-related gray matter loss was distributed mainly in medial temporal, anterior cingulate, and medial frontal lobes White matter loss was distributed in frontal and temporal regions T2DM was associated with poorer visuospatial construction, planning, visual memory, and speed independent of age, sex, education, and vascular risk factors Moran C. et al. Diabetes Care 2013;36:4036-4042

7. CONCLUSIONS Cortical atrophy in T2DM resembles patterns seen in preclinical Alzheimer disease Neurodegeneration rather than cerebrovascular lesions may play a key role in T2DM-related cognitive impairment Moran C. et al. Diabetes Care 2013;36:4036-4042