1. Dr. Steve LaRowe Assistant Professor of Psychiatry Center for Drug and Alcohol Programs How drugs and alcohol affect the brain

2. Part I How the brain works

6. B They use chemicals called neurotransmitters B One cell gives its neurotransmitters to another cell to tell it what to do B This process is called neurotransmission Brain cells (neurons) talk to each other

7. Basic Wiring of the Brain

9. Summary 1. Our brain controls how we feel, think and act 2. Brain cells are called neurons 3. Neurons communicate with each other with chemicals called neurotransmitters 4.This process is called neurotransmission

10. Part II How drugs affect the brain

11. STOP

12. Feeling Pleasure and Reward: the Dopamine Way!

13. The Reward System Food, water, warmth (natural reinforcers) cause dopamine release in the nucleus accumbens All drugs of abuse artificially cause neurotransmission in the nucleus accumbens to an extreme degree

14. DRUG EFFECTS: TOO MUCH OF A GOOD THING! ? ? ? STOP?

15. What does this mean to your brain? It means that you try drugs you will probably like them. Because you like them, you’ll do it again. And then again. And then again….. Then what?

16. Brain changes.. Too much dopamine, and the body “turns down the volume” on its own…

17. Your brain changes Over time, drugs of abuse highjack your brain: your neurons change physically--one result is that you lose the ability to feel pleasure You will need more and more of the drug just to feel “normal”--like you used to be before you took drugs You lose the ability to “take or leave” the drug--you HAVE to have it, aka addiction

18. Addiction is a chronic brain disease Recovering addicts struggle for the rest of their lives not to use drugs or alcohol again Most recovering addicts relapse The brain of an addicted person remains changed for a long, long time--scientists don’t know if it ever returns to “normal”

19. Positron Emission Tomography (PET)

20. Brain activity is changed by drugs Cocaine Abuser (10 days later) NormalCocaine Abuser (100 days later)

21. Part III Drugs, Alcohol, and Middle School

22. Warning: Many people start in middle school! InfantChildAdolescentAdult Older Adult Age of first use, number of initiates

23. Warning: Your Brain’s not done growing! Blue represents maturing of brain areas. TOP VIEW. SIDE VIEW. IMAGES OF BRAIN DEVELOPMENT IN HEALTHY CHILDREN AND TEENS (AGES 5–20) Age 5Age 20

25. Not everyone’s doing it…

26. Warning: Drugs can ruin a person, a very short time!

27. The bottom line

28. Alcohol Facts Drinking impairs judgment, coordination, can increase feelings of depression Binge drinking: 4 drinks for women and 5 drinks for men over a four-hour period. Less time, more risk; younger people, more risk. Alcohol poisoning is a severe, physical reaction to an overdose of alcohol. The brain, struggling to deal with the overdose of alcohol and lack of oxygen, begins to shut down the voluntary functions that regulate breathing and heart rate.

29. Cigarette Facts 440,000 People Die from cigarette- related causes per year (more than all the soldiers in WWII) 3,000 die from second hand smoke Causes COPD, Emphysema, Lung Cancer