1. Cell Reproduction and DNA

2. History of Cells During the 17 th century, the invention of the microscope helped scientists examine drops of blood, scrapings from their teeth, and other small things. In 1665, Robert Hooke cut a thin slice of cork and looked at it under his microscope…he saw squares and named those squares cells. In the 1830’s, plants were examined an were determined to be made of cells also. http://www.youtube.com/watch? v=4OpBylwH9DU

3. The Cell Theory Rudolph Virchow hypothesized that: All organisms are made up of one or more cells The cell is the basic unit of organization in organisms All cells come from cells

4. Cell Review There are two types of cells: Prokaryotic cells don’t have a nucleus. Ex: bacteria Eukaryotic cells have a nucleus Ex. Plants and animal cells

5. Cell Structures Cell walls: outer coverings that protect cells and give them shape. Cytoplasm: gel like substance that contains the cytoskeleton…gives and maintains shape of the cell Organelles: the structures inside of the cell

6. Cell Structures Nucleus: directs all cell activities…contains DNA (information that contains the code of all cell’s structure and activities). Mitochondria: a structure where energy is released from the breakdown of food into CO2 and water. Ribosomes: a structure that makes proteins needed for chemical reactions

7. Cell Division and Mitosis Cell division — increases the number of cells and causes many- celled organisms to grow The Cell Cycle — series of events that takes place from one cell division to the next Cells have periods of formation, growth and development, and death called life cycles. http://www.youtube.com/watc h?v=L0k-enzoeOM

8. Cell Division and Mitosis Chromosome—structure in the nucleus that contains hereditary material Interphase — most of the life of any eukaryotic cell, or cell with a nucleus, is spent in a period of growth and development. During interphase, a cell duplicates its chromosomes and prepares for cell division. After interphase, the nucleus divides, and then the cytoplasm separates to form two new cells. Mitosis - process in which the nucleus divides to form two identical nuclei

9. Prophase Nucleolus and nuclear membrane disintegrate. Centrioles move to opposite ends of the cell. Spindle fibers begin to stretch across the cell.

10. Metaphase Pairs of chromatids line up across the center of the cell.

11. Anaphase Each centromere divides. Each pair of chromatids separates and moves to opposite ends of the cell.

12. Telophase spindle fibers disappear and a new nucleus forms.

13. Animal vs. Plant Cells Cytokinesis: Division of the Cytoplasm—for most cells, the cytoplasm separates after the nucleus divides In animal cells, the cell membrane pinches in the middle and the cytoplasm divides. In plant cells, a cell plate forms.

14. Extra Large, Semi-3D Mitosis Thingy Divide into groups of 3-4. Using a large piece of paper, divide up the steps of Mitosis, including Interphase, and make a large diagram. All of the essential cell structures must be labeled in each step. Describe what happens in each step. Pick one cell structure in each step and make it 3D…a different structure must be 3D in each step.

15. Cell and Mitosis Quiz 1.Explain one of the main ideas of the Cell Theory. 2.What is the function of the nucleus in the cell? 3.In your own words, explain the purpose of mitosis.

16. Results of Mitosis Each cell in your body, except sex cells, has a nucleus with 46 chromosomes. Allows growth and replaces worn out or damaged cells Asexual reproduction — a new organism is produced from one parent organism. An organism with no nucleus divides (bacteria) into two identical organisms by fission. Budding — a small, exact copy of the adult grows from the body of the parent. In regeneration, a whole new organism grows from each piece of the parent.

17. Section 2: Sexual Reproduction and Meiosis Sexual reproduction—two sex cells, usually an egg and a sperm, come together. Fertilization—the joining of an egg and a sperm, generally from two different organisms of the same species –Sperm are formed in the male reproductive organs. –Eggs are formed in the female reproductive organs. –A cell that forms from fertilization is a zygote. Following fertilization, cell division begins and a new organism develops.

18. Sexual Reproduction Human body cells are diploid, because they have 23 pairs of similar chromosomes = 46 total chromosomes. Human sex cells are haploid, because they have 23 single chromosomes

19. In Meiosis I, each chromosome is duplicated, just as in mitosis. The steps of Meiosis I are identical to mitosis… http://www.youtube.com/watch?v=qCLmR9-YY7o&feature=fvsr

20. In meiosis II, the nuclei divide and the chromatids separate, producing four cells with half the number of chromosomes of the original nucleus.

21. Prophase II: Duplicated chromosomes and spindle fibers reappear in each new cell. Metaphase II: Duplicated chromosomes move to the center of the cell. Each centromere now attaches to two spindle fibers instead of one. Anaphase II: The centromere divides and the chromatids separate and move to opposite ends of the cell. Each chromatid is now an individual chromosome. Telophase II: Spindle fibers disappear, nuclear membrane forms around each set of chromosomes, cytoplasm divides

22. Mitosis/Meiosis Venn Diagram You must have at least 4 points in each section (12 total) You must include 4 pictures in each section… They can correspond with your 4 points or can be separate.

23. Chapter 4 Section 3 DNA – Deoxyribonucleic Acid: –a chemical that contains information that an organism needs to grow and function –Watson and Crick described first accurate model of DNA in 1953. They were awarded the Nobel Prize for physiology in 1962 Some scientists believe the discovery of DNA was the most important biological event of the century Why? – Led to improved plants and animals, and to help in detecting and preventing inherited disorders http://www.youtube.com/watch?v=hnSPGlpZx_Q

24. The structure of DNA is similar to a twisted ladder. The sides of the ladder are made up of sugar-phosphate molecules. The rungs of the ladder are made up of nitrogen bases. The 4 nitrogen bases are Adenine, Thymine, Guanine and Cytosine. Adenine always pairs with Thymine Guanine always pairs with Cytosine

25. Before a cell divides, its DNA duplicates itself by unwinding and separating its sides. Each side becomes a pattern on which a new side forms.

26. Genes – sections of DNA on a chromosome Unit of heredity Contain instructions for making specific proteins

27. DNA Double Helix Replica Day One/Two 1.Take 2 “backbone” sheets, and 1 of each of the colored sheets of base pairs. 2.Cut out one sheet of “backbone” pieces and half of each of the base pairs. 3.Using your DNA blueprint, assemble your DNA double helix (Only bolded base pairs today). 4.Make sure you pair the correct base pairs together!

28. RNA carries the codes for making proteins from the nucleus to the ribosomes in the cytoplasm. Messenger RNA carries the code that directs the order in which the amino acids bond. Ribosomal RNA makes up ribosomes, where proteins are built. Transfer RNA brings amino acids to the ribosomes to build the protein.

29. RNA has nitrogen bases like DNA but contains Uracil instead of Thymine. So.. Adenine pairs with Uracil Guanine pairs with Cytosine

30. Mutations - any permanent change in the DNA sequence of a cell's gene or chromosome –Can be caused by outside factors like X rays, sunlight, and some chemicals –A change in a gene or chromosome can change the traits of an organism.