1. I-BIO Frontier Fellowship 모집 연구 분야 0 1. 국가과학자 연구주제

2. I-BIO Frontier Fellowship 모집 연구 분야 1 Aging mechanism Biochemical nature, endocytosis mechanism of superoxide vesicle in Arabidospis Systems genetics approaches to understand aging and senescence in plants Systems genetic approaches to understand aging in C. elegans including mapping of death 참여교수 : 남홍길 RNA systems biology and chemistry RNA imaging in vivo and spatial regulation of RNA in plants and others RNA-based network in plants and C. elegans RNA structure mapping: AFM-based experiment RNA modification and its role Modulation of RNA species in development 참여교수 : 남홍길 Photoresponses Systems approaches and imaging approaches for plant photoresponses and circadian rhythms 참여교수 : 남홍길 2. I-BIO 공동연구 분야

3. 2 Photosynthesis Assembly and dynamics of photosynthetic complex with superresolution imaging Photochemical reaction/dynamic modeling and spectroscopic, and imaging experiment. Imaging photochemistry and physics with AFM and fast spectroscopy 참여교수 : 남홍길 Imaging technology For superresolution imaging For dynamic imaging For high throughput imaging 참여교수 : 남홍길 Chemical Genetics For photosynthetic components For controlling plant development such as flowering For controlling lignin using reverse chemical genetics 참여교수 : 남홍길 I-BIO Frontier Fellowship 모집 연구 분야

4. 3 Title: Mathematical modeling and analysis of biological systems Summary: We aim to apply mathematical modeling, and numerical and analytical analysis to discover underlying principles of systems and to develop systematic theories for biological phenomena. 참여교수 : 남홍길, 황형주 Title: Non-Labeling Single Biomolecule Imaging Technology: Force-Based Atomic Force Microscopy (Joon Won Park) Summary: Dynamic force microscopy has been used widely to reveal behaviors of single biomolecules during the last 20 years. Precise control of surface architecture of the AFM probe revealed that the capacity of the force-based tool was beyond what people have seen. In particular, guaranteeing truly the single molecular interaction during the measurement enables to "see" biomolcules such as proteins and DNA/RNA one by one with high accuracy. Therefore, it now is possible to map the biomolecules on a solid substrate as well as tissue at the single molecule level. Numerous applications can be envisaged with the non-labeling and non-amplification approach showing the ultimate resolution. 참여교수 : 남홍길, 박준원 Title: RNA bases biologycal network: technology development and application Summary: multiplexed single cell mRNA counting 참여교수 : 남홍길, 이남기 3. I-BIO 공동 연구 과제

5. I-BIO Frontier Fellowship 모집 연구 분야 4 Title: Dynamics of membrane protein complex: Single molecule biophysics Summary: dynamic biology with super-resolution imaging technique 참여교수 : 남홍길, 이남기 Title: Decoding RNA networks governing aging dependent senescence. Summary: - Objective: Decoding of functional RNA networks governing aging-dependent senescence - Contents: 1) generation of RNA & small RNA deep sequencing data of young and aged plants, 2) identification of functional RNA associated with aging-dependent senescence, 3) measurement of RNA-RNA and RNA-protein interactions involving the identified functional RNAs, 4) refinement of measured RNA-RNA and RNA-protein interactions based on in-silico RNA interaction prediction methods, 5) reconstruction of aging associated RNA networks using refined RNA interaction, 6) identification of key functional RNA network modules, and 7) experimental validation of the functional contexts of operations of RNA network modules using imaging, genetics, molecular and cellular biological technologies. - Benefits: Expansion of current limited knowledge of miRNA and few RNA-protein interactions based small RNA networks into general functional RNA networks including interactions of functional RNAs with key elements in the systems. Platform technologies for decoding functional RNA networks can be established, which can be used to study RNA related key cellular networks in living organisms. 참여교수 : 남홍길, 황대희

6. I-BIO Frontier Fellowship 모집 연구 분야 5 Title: Quantum chemical phenomenon in biology Summary: In this project, quantum chemical behaviors in biological systems (e.g. photoproteins and photosynthetic systems) will be studied on a theoretical basis. 참여교수 : 남홍길, 이영민 Title: Study of ultrafast dynamical phenomena in photosynthesis Summary: In this project, we are interested in various dynamical processes occurring in photosynthesis and related subjects such as Photon capture, electron transfer, oxygen reduction and quantum coherence, using femtosecond / attosecond optics. This study will also have close collaboration with Prof. Nam, Hong Gil for sample preparation and with Prof Lee, Young Min and Prof. Park, Ki Soo for theoretical support. 참여교수 : 남홍길, 김동언 Title: tRNA population dynamics in aging process Summary: 1) development of precise and efficient tRNA population analysis method 2) analysis of correlation between tRNA population and aging 참여교수 : 남홍길, 정규열