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Fatty liver (Steatosis) Definition: It is the accumulation of excessive amount of lipids more than 4% of the weight of the liver leading to liver cells.

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Presentation on theme: "Fatty liver (Steatosis) Definition: It is the accumulation of excessive amount of lipids more than 4% of the weight of the liver leading to liver cells."— Presentation transcript:

1 Fatty liver (Steatosis) Definition: It is the accumulation of excessive amount of lipids more than 4% of the weight of the liver leading to liver cells replacement by fibrous tissues with subsequent liver cirrhosis.

2 Causes of Fatty liver 1.Over feeding of fats. 2.Over feeding of carbohydrates. 3.Over mobilization of F.A from depot to liver. 4.Decreased oxidation of F.A. due to: A. Deficiency of pantothenic acid. B. Deficiency of carnitine. C. Increased NADH/NAD ratio as in alcoholism. 5. Decreased mobilization of fats from liver to blood.

3 Definition: These are factors which facilitate transport of TAG from liver to be utilized by the tissues. These factors may be either: 1. Substances needed for phospholipid biosynthesis. 2. Substances needed for protein biosynthesis.

4 1.Substances needed for phospholipid biosynthesis. A. Essential F.A. B. Inositol. C. Choline D. Substances needed for choline biosynthesis as Methionine,Glycine betaine,Folic acid and Vit.B12 2. Substances needed for protein biosynthesis: A. Protein of high biological value. B. Essential a.a (e.g Methionine). C. Non-essential a.a (Serine).

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7 Antilipotropic Factors Definition: These are substances which inhibit mobilization of fats from the liver. Causes: 1. Substances Which inhibit phospholipid biosynthesis. 2. Substances Which inhibit protein biosynthesis.

8 1.Substances Which inhibit phospholipid biosynthesis as in over feeding of cholesterol, niacin and biotine. 2. Substances Which inhibit protein biosynthesis like carbon tetracholoride, choloroform, phosphorus, arsenic and ethionine

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