1. Cardiac Modeling of Steady-State Transients in the Ventricular Myocyte Raymond Tran University of Queensland July 3 2013 UCSD PRIME

2. Research Proposal To expand the Shannon et al cardiac model and its limitations by accounting for change in intracellular potassium concentration. Nimrod is a modeling system that conducts parametric sweep across multiple computing resources. Specifically, Nimrod will be integrated with the model to look for steady-state values of AP, [Ca] i, [Na] i, [K] i. Nimrod

3. Methods 1. Will first search for the steady-state transients by testing values of applied current and its duration in the cell. 2. Will also examine the parameters of the Na-K pump and its effect on AP and the change of intracellular Ca, Na, and K over time.

4. Progress of Experiment In the process of running first test experiment on Nimrod/G. Will conduct parametric sweep of the applied current in the model. Current objective is to run multiple experiments with different parameters to find steady-state transients.

5. Brisbane, Queensland Left: The Brisbane Wheel, located in central Brisbane. Top right: Bridge at Indooroopilly, a small town approximately 6 kilometers from the university. Bottom Right: The Brisbane River.

6. Acknowledgements University of California, San Diego Dr. Anushka Michailova, Department of Bioengineering. UCSD PRIME – Dr. Peter Arzberger, Dr. Gabriele Wienhausen, Ms. Teri Simas. University of Queensland Dr. David Abramson, Centre for Research Computing Hoang Nguyen, Ph.D. student at University of Queensland