1. Clinical Measures Genotype Local Storage BIRN Rack SRB MCAT HID/ XNAT/ LONI DUP Calibration & Analysis Tools GRID Portal Mediator Institution A BIRN Rack SRB MCAT Institution B … Workflow & Control: - Queries (identify subject populations, extract data, etc.) - Statistical Analysis - Download Data for: > Visualization > More Statistics > More Processing - Interoperable Queries (literature, homology, other databases, etc.) Human Data Protection (De-identification Upload Pipeline, DUP) Standardized Acquisition Protocol Institution C BIRN: Informatics Architecture Local DB HID/ XNAT/ LONI

2. AHM 2005 Informatics - Project Goals  Databasing and Information Management across sites  Data and Tool Interoperation Ontology for Data Integration  Provenance  Enhance Workflow Options  Statistical Interface  Knowledge Management Semantic Web Functionality  Semi-Public & Public Access to Data

3. AHM 2005 Informatics - Achievements Since Oct04 DATABASE TECHNOLOGIES  Multiple HID’s in operation and with Data (~8 sites)  More Clinical Assessments in HID  Improved End-to-end Uploading to SRB/HID (in cooperation w/ fBIRN)  Multiple XNAT’s in operation with Image, Demographic & Volumetric Data (5 instances/ 3 sites)  Provenance Structures Incorporated into XNAT & HID  Controlled Release Cycle of Tools (BIRN Release 2.0 6/14/2005)

4. AHM 2005 Informatics - Achievements Since Oct04 KNOWLEDGE MANAGEMENT  Haystack/Eclipse Semantic Environment PUBLIC DATA  Public Data (OASIS & 10/10 UCSD) to be Released (any day now…) UNRELATED ACTIVITIES  Red Sox win World Series…

5. XNAT Build Report Export Control Browse Drill Down XNAT

6. AHM 2005 Informatics - Achievements Since Oct04

7. Haystack/Eclipse Workspace

8. AHM 2005 Informatics - Discussion Items  Continue the expansion of BIRN-compliant Data Information Systems at Multiple Locations  Data Interoperation (Multiple instances of pool-able data across cites, within and between management platforms)  Increase Availability of Completely Public Data  Workflow  Ontology

9. AHM 2005 Informatics - Oct 2006 Goals To be fleshed out over next two days…  More HID and XNAT Sites & Data (UCI & JHU & +++)  Inter-site Information Sharing Between Database Systems - MAD ‡ & SASHA datasets as exemplars: ‘Manual’ and ‘Automated’ Mediation Amongst Systems  XML Data ‡ Interoperation Between XNAT & HID (w/ fBIRN)  Continue Controlled Release Cycle of Tools (BIRN Release 2.1?) - Incorporate XNAT & HID/CALM/GAME Updates  mBIRN Public Data Portal 10/10, OASIS (~400) ‡, ADNI (~100), MIRIAD (~300), others  Workflow  Ontology

10.  End