1. rh Lecture 9 Slides

2. LIPID CATABOLISM

3. lipid menagerie phospholipid triglyceride

4. from McDonalds to Metabolism… fig17-1

5. from McDonalds to Metabolism…

6. The chylomicron: a lipoprotein fig17-2

7. mobilization of glycerol fig17-4

8. fig17-5 connecting the FA to CoA-SH

9. fig17-5 connecting the FA to CoA-SH good leaving group

10. fig 19-1

11. Carnitine: Charon* of the matrix! * you know, the boatman on the River Styx

12. Carnitine: Charon* of the matrix! * you know, the boatman on the River Styx

13. fig17-6 Transport of acyl-carnitine into the matrix rate-limiting step for oxidation of FAs

14. oxidation of fatty acids: three steps, one new… fig17-7

15.  -oxidation: taking it two carbons at a time fig17-8

20. iterated metabolic pathway

23.  -oxidation challenges… monounsaturated FA odd-carbon FA

24.  -oxidation challenges… monounsaturated FA polyunsaturated FA odd-carbon FA

25.  -oxidation of a mono- unsaturated fatty acid fig17-9

26.  -oxidation challenges… monounsaturated FA polyunsaturated FA odd-carbon FA

27. what about 3-carbon leftovers? fig17-11

28. what about 3-carbon leftovers? fig17-11

29. what about 3-carbon leftovers?

30. the coenzyme B 12 reaction box17-2

31. deoxyadenosyl cobalomin or coenzyme B 12 box17-2

34. comparison of FA oxidation mitochondria vs. peroxisomes box17-13 catalase

35. fatty acid metabolism in seeds… fig17-14

36. enzyme evolution in fatty acid oxidation fig17-15 one protein

37. ketone bodies fig17-16

38. fig17-18 formation of ketone bodies from Ac-CoA

39. formation of ketone bodies from Ac-CoA fig17-18

40. formation of ketone bodies from Ac-CoA fig17-18

41. formation of ketone bodies from Ac-CoA fig17-18

42. formation of ketone bodies from Ac-CoA

43. metabolism of a ketone body fig17-19

47. liver synthesis of ketone bodies when TCA activity is low fig17-20