1. Integration of Metabolism Jack Blazyk 3/4/04

2. Well-Fed Conditions

3. Only in America

4. Glycolysis Glycogenesis Pentose Shunt Fatty Acid Synthesis Cholesterol Synthesis Triglyceride Synthesis Well-Fed Liver

5. Glycolysis Pentose Shunt Fatty Acid Synthesis Cholesterol Synthesis Triglyceride Synthesis Well-Fed Adipose

6. Well-Fed Muscle Glycogenesis

7. Insulin RBC Liver Muscle Adipose Brain Gut Portal Vein Lymphatics Glucose Glycogen Glucose CO 2 + H 2 O  Protein TG Urea Pancreas Glucose  TG Pyruvate Lactate Chylomicrons VLDL Glycogen CO 2 + H 2 O Well-Fed State

8. Fasting Conditions

9. Fasting Liver Gluconeogenesis Fatty Acid Oxidation Ketone Body Synthesis Glycogenolysis

10. Fasting Adipose Fatty Acid Oxidation Triglyceride Breakdown No Uptake

11. Fasting Muscle Fatty Acid Oxidation Ketone Body Utilization No Uptake

12. Glucagon RBC Liver Muscle Adipose Brain Gut Portal Vein Lymphatics Glycogen Glucose CO 2 + H 2 O Pancreas Pyruvate CO 2 + H 2 O Early Fasting State CO 2 + H 2 O FA Lactate

13. Glucagon RBC Liver Muscle Adipose Brain Gut Portal Vein Lymphatics CO 2 + H 2 O Pancreas Pyruvate CO 2 + H 2 O Extended Fasting State KB Lactate FA Glycerol FA CO 2 + H 2 O Protein  Cortisol Glucose Urea

14. Insulin RBC Liver Muscle Adipose Brain Gut Portal Vein Lymphatics Glucose Glycogen Glucose CO 2 + H 2 O  Protein TG Urea Pancreas Glucose  TG Pyruvate Lactate Chylomicrons VLDL Glycogen CO 2 + H 2 O Well-Fed State

15. Glucagon RBC Liver Muscle Adipose Brain Gut Portal Vein Lymphatics CO 2 + H 2 O Pancreas Pyruvate CO 2 + H 2 O Extended Fasting State KB Lactate FA Glycerol FA CO 2 + H 2 O Protein  Cortisol Glucose Urea

16. http://arbl.cvmbs.colostate.edu/hbooks Useful Endocrine & Metabolism Link

23. Regulation Carnitine Shuttle CoA-SH CH 3 -(CH 2 ) 14 -C-S-CoA O = Cytoplasm Matrix CH 3 -(CH 2 ) 14 -C-S-CoA O = Malonyl-CoA X