1. Chapter 17 Immunoregulation

2. To keep the individual homeostasis by regulating the balance between immunocyte and immunocyte, between immunocyte and immune molecule and between immune system and nerve system /endocrine system.

3. Content Immuno-regulation on genetic level
Immuno-regulation on molecular level
Immuno-regulation on cellular level
Immuno-regulation on individual and population level

4. Section I regulation on genetic level
Genes encode TCR and BCR
Genes encode immune response regulating molecules:
MHC
Immune response gene,Ir gene(HLA)

5. Section II. Immunologic regulation on molecular level
Regulation of antigen to Ir
2. Regulation of antibody and Ag-Ab complex to Ir
antibody feedback inhibition:

6. 1. Regulation of antigen Route of Ag entrance Dosage of Ag
Structural characteristic: antigen competition

7. 2. Regulation of antibody
（1）regulation by immune complex
When Ab increase, it binds to Ag and weaken IR
Regulation of Ag-Ab complex to IR----- Antibody feedback inhibition
IgM----stimulate IR
IgG----reduce IR

9. antibody feedback inhibition:Ag Ag
FcrR II
BCR
BCR
ITIM
Antibody Feedback Inhibition

11. (2) The idiotypic networks and immunologic regulation
Idiotypic determinant or idiotype: a unique determinant on an antibody or BCR/TCR molecule,usually formed by one or more of the hypervariable regions. anti-idiotypic antibody (or TCR): antibodies against idiotype of antibodies or TCRs

12. Idiotypic networks
A network of complementary interactions involving idiotypes and anti-idiotypic antibodies(or TCR).
Ag——Ab1——Ab2——Ab

13. 3.regulation of complements
Promote APC capture antigens:
CR1 receptor on APC capture C3b-Ag-Ab complex
2) Promote the activation of B cell
CR2 on B cell

14. 4. Immunoregulation by co-stimulatory signal
B7----CD28
----CTLA-4
5. The regulation of signal transduction
(1). ITAMs and ITIMs
(2). Phosphorylation and dephosphorylation

15. PartⅢ The immunoloregulation on cellular level
1. Regulation of T cell subsets Th
CD4+CD25+Treg
2. Regulation of B cells
3. AICD (activation induced cell death)

16. Th1
+IL-12
+IL-4
IL-2 IFN-g
IL-4 IL-10
inhibit
Cell mediated immunity
Humoral immunity
Th0
Th2
Th1 和 Th2 细 胞 的 分 化

18. AICD

19. SectionIV The immunologic regulation on individual and population level
I) Nerve-endocrine-immune system regulation networks II) Immune system regulate the nerve and endocrine system.