1. Kingdom: Viruses Biology 11 G. Burgess 2009

2. What’s a virus  Complex molecules made of a protective protein coat that either covers a RNA or DNA segment.  They are not ‘living’ yet are able to reproduce  They must interact with a living cell in order to generate new viral complexes

3. Structure of a virus Protein Coat Protein attachment sites RNA segments Every fall/winter we are infected with the flu virus. As the virus is transferred from one host to another, the RNA is changed by our own cells. The proteins on the outside of the virus allow it to attach to proteins on our cell membranes. Once attached, the virus is able to release its RNA into our cells to take control of ribosomes and make copies of itself.

4. Classification of Viruses  Viruses are first classified by their host Viruses infect all living organisms from monera to fungi to animalia. MORPHOLOGICAL CLASSIFICATION  They are also classified by their biochemical make up and structure GENOMIC CLASSIFICATION

5. The Baltimore Classification System  Classifies viruses into seven groups by comparing their nucleic acid (DNA or RNA), strandedness (single-stranded or double-stranded), and method of replication.nucleic acid Group I: double-stranded DNA viruses Group II: single-stranded DNA viruses Group III: double-stranded RNA viruses Group IV: positive-sense single-stranded RNA viruses Group V: negative-sense single-stranded RNA viruses Group VI: reverse transcribing Diploid single- stranded RNA viruses Group VII: reverse transcribing Circular double- stranded DNA viruses

6. DNA viruses  Group 1 Double stranded DNA  ie. Herpesviridae (herpes) Poxviridae (small pox)  Group 2 Single strand DNA  ie. Parvovirus

7. Human Papilloma virus Gynecological tests check for signs of this cervical cancer causing virus.

8. RNA viruses  Group 3 Double strand RNA Ie. Rotaviruses  Group 4 Positive-sense single RNA strand ie. SARS virus, rubella virus, polio, HIV  Group 5 Negative- sense single RNA strand ie. Measles, mumps, rabis

9. RNA Small pox, Variola virus

10. Life Cycle of a virus  2 parts; lytic and lysogenic cycle  Lytic cycle: Virus identifies and infects a host cell Virus takes control of cell’s organelles (namely the ribosomes) and self replicates using the materials within the cell. Once new viruses are generated, the virus causes the host cell to lysis(break open) and release the newly created viruses.

11. Functioning Cycle of a virus  Lysogenic Cycle: Viral DNA may infect the host cell’s DNA. This is called a provirus. Proviruses do not allow other viruses to infect the cell They may carry on normal everyday activities of the cell or cause changes in the cell or organism over time. These viruses are stimulated by environmental factors causing the production of new viruses and the lysis of the host cell.

12. Questions  Pp. 338 #1-8 Text: Biology 11, Nelson, 2002.

13. Bibliography  Biology Living Systems, Glencoe, 1994.  Virus Types, http://www.mansfield.ohio- state.edu/~sabedon/biol3025.htm, S.Abedon, accessed Nov.8, 2006http://www.mansfield.ohio- state.edu/~sabedon/biol3025.htm  ManBir Online, http://manbir-online.com/index.htm, accessed Nov.8,2006.http://manbir-online.com/index.htm  ICTVdB, http://phene.cpmc.columbia.edu/, Dr.C.Büchen-Osmond, accessed Nov.8, 2006.http://phene.cpmc.columbia.edu/