1. Objective:To assess the effect of various clopidogrel and aspirin regimens on major CV events and ST in ACS patients undergoing PCI. Study:Multicenter, randomized trial. 2 x 2 factorial design. Population:ACS patients (STEMI, NSTEMI, unstable angina with ST depression). Endpoint: Composite of CV death, MI or stroke. Objective:To assess the effect of various clopidogrel and aspirin regimens on major CV events and ST in ACS patients undergoing PCI. Study:Multicenter, randomized trial. 2 x 2 factorial design. Population:ACS patients (STEMI, NSTEMI, unstable angina with ST depression). Endpoint: Composite of CV death, MI or stroke. CURRENT-OASIS 7

2. Randomized N=25086 Double dose clopidogrel N=12520 Standard dose clopidogrel N=12566 High dose aspirin N=6253 Low dose aspirin N=6267 High dose aspirin N=6254 Low dose aspirin N=6312 CAG PCI ≤ 72h Double + high N=4298 Double + Low N=4262 Standard + High N=4326 Standard + Low N=4376 No PCI N=7823

3. p=0.018p<0.001p=0.71p=0.039p=0.009 Event rate at 30 days (%) CURRENT-OASIS 7

4. p=0.76p=0.35p=0.80p=0.62p=0.22 CURRENT-OASIS 7

5. Mehta et al. Lancet 2010;376:1233-43 Conclusion:In patients undergoing PCI for ACS a 7 day double dose clopidogrel regimen was associated with a reduction in CV events and ST. No difference was found between high and low dose aspirin. CURRENT-OASIS 7