1. FAME 2 year Objective:To investigate the 2-year outcome of PCI guided by FFR in patients with multivessel CAD. Study:Multicenter, single blind, randomized trial. Population:Patients with stable and unstable angina and multivessel CAD (≥ 50% DS) in native coronary arteries. Endpoint: Composite of death, MI (Q wave, CKMB > 3xULN), any revascularization at 2 year f-up. Objective:To investigate the 2-year outcome of PCI guided by FFR in patients with multivessel CAD. Study:Multicenter, single blind, randomized trial. Population:Patients with stable and unstable angina and multivessel CAD (≥ 50% DS) in native coronary arteries. Endpoint: Composite of death, MI (Q wave, CKMB > 3xULN), any revascularization at 2 year f-up.

2. MVD patients Referred for PCI n=1005 Identification of all lesions ≥ 50%DS planned for PCI Angiography guided n=509 FFR guided PCI if FFR ≤ 0.8 n=509 FAME 2 year

3. Event rate at 2 year (%) p=0.08p=0.25p=0.03p=0.30p=0.02 FAME 2 year

4. Pijls et al. J Am Coll Cardiol 2010;56:177-84 Conclusion:FFR measurement in patients with multivessel disease undergoing PCI with DES reduces mortality and myocardial infarction at 2 years compared to angiography guided PCI. FAME 2 year