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Pai JK et al. N Engl J Med 2004; 351:2599-2610. Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP<1.0 mg/L (RR=1.0) PopulationCRP.

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Presentation on theme: "Pai JK et al. N Engl J Med 2004; 351:2599-2610. Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP<1.0 mg/L (RR=1.0) PopulationCRP."— Presentation transcript:

1 Pai JK et al. N Engl J Med 2004; 351:2599-2610. Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP<1.0 mg/L (RR=1.0) PopulationCRP 1.0-2.9 mg/L, RR (95% CI) CRP >3.0 mg/L, RR (95% CI) p for trend Women (patients, n=239; controls, n=469) 1.17 (0.69-2.00) 1.53 (0.89-2.62) 0.09 Men (patients, n=265; controls, n=529) 1.60 (1.09-2.34) 1.79 (1.14-2.83) 0.03 Men and women1.44 (1.05-1.96) 1.68 (1.18-2.38) 0.008 *Adjusted for age, smoking status, month of blood sampling, parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index, diabetes, and hypertension; and in women only, also adjusted for fasting status at time of blood sampling and postmenopausal hormone therapy status.

2 Relative CHD risk by baseline CRP plasma levels, by quintiles relative to lowest quintile (RR=1.0) Pai JK et al. N Engl J Med 2004; 351:2599-2610. Quintiles by sex Adjusted for case- matching criteria,* RR (95% CI) Further adjusted for TC:HDL-C, BMI, other risk factors,** RR (95% CI) Further adjusted for diabetes and hypertension, RR (95% CI) Women Quintile 21.28 (0.74-2.23) 1.17 (0.64-2.14) 1.23 (0.66-2.32) Quintile 31.03 (0.59-1.81) 0.81 (0.43-1.52) 0.89 (0.46-1.72) Quintile 41.54 (0.91-2.63) 1.17 (0.64-2.14) 1.22 (0.65-2.30) Quintile 52.18 (1.30-3.64) 1.86 (1.00-3.46) 1.61 (0.84-3.07) —p for trend<0.0010.0080.08 *Age, smoking status, month of blood sampling; in women only, also adjusted for fasting status at time of blood sampling. **Parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index (BMI); in women only, also adjusted for postmenopausal hormone therapy status.

3 Relative CHD risk by baseline CRP plasma levels, by quintiles relative to lowest quintile (RR=1.0) Pai JK et al. N Engl J Med 2004; 351:2599-2610. Quintiles by sex Adjusted for case- matching criteria,* RR (95% CI) Further adjusted for TC:HDL-C, BMI, other risk factors,** RR (95% CI) Further adjusted for diabetes and hypertension, RR (95% CI) Men Quintile 21.81 (1.04-3.17) 1.75 (0.97-3.14) 1.75 (0.97-3.16) Quintile 32.00 (1.15-3.50) 1.83 (1.02-3.30) 1.74 (0.96-3.15) Quintile 42.74 (1.59-4.71) 2.27 (1.26-4.09) 2.14 (1.18-3.88) Quintile 53.29 (1.91-5.65) 2.73 (1.51-4.96) 2.55 (1.40-4.65) —p for trend<0.0010.0070.02 *Age, smoking status, month of blood sampling; in women only, also adjusted for fasting status at time of blood sampling. **Parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index (BMI); in women only, also adjusted for postmenopausal hormone therapy status.

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