1. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial Participant Website The I-SPY 2 TRIAL is a clinical trial that is designed to test several investigational drugs for breast cancer. The goal of this trial is to quickly learn which patients are most likely to benefit from these investigational by learning about each patient’s cancer biology and using imaging techniques.

2. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial Information about I-SPY 2 Commonly Asked Questions about the I-SPY 2 TRIAL How does the I-SPY 2 TRIAL work? What is a biomarker and how are they being used in I-SPY 2? What is a MRI scan and what does it mean to me? What is a core biopsy and what does it mean to me? I nvestigation of S erial studies to S erial studies to Predict Predict Y our Y our T herapeutic R esponse with I maging A nd mo L ecular analysis mo L ecular analysis

3. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial Information about I-SPY 2 Commonly Asked Questions about the I-SPY 2 TRIAL What happens if I consider joining the I-SPY 2 TRIAL? How do I know if I am eligible for the I-SPY 2 TRIAL? What biomarkers will be used to see if I am eligible for the I-SPY 2 TRIAL? What is MammaPrint ® ? What MammaRrint ® score do I need to participate in I-SPY 2? Why will I receive treatment before surgery in I-SPY 2? Why will I receive 2 different chemotherapy treatments? If I agree to be in I-SPY 2, how soon will I be able to start my treatment? How likely am I to receive an investigational drug if I join I-SPY 2? If I do receive an investigational drug, who pays for the investigational drug, what will it be, and what are the potential short and long term side effects? How many MRIs will I have and how long will each one take? Who will pay for the MRIs that I will have? How many times will tissue be collected, who will pay for the collection, and how will the tissue be collected? How many times will my blood be collected, who will pay for the collection, and how will the blood be collected? What will my tissue and blood samples be used for? Will I be told the results of the tests done from my tissue and blood samples? If I join I-SPY 2, how long will I be in the study? If my cancer does not go away completely after neoadjuvant treatment, what options are available to me for additional treatment? This trial is called I-SPY 2. What was I-SPY 1 and what was learned from it? Whom may I contact if I have additional questions about I-SPY 2?

4. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial Information about I-SPY 2 TRIAL Commonly Asked Questions about the I-SPY 2 TRIAL What happens if I consider joining the I-SPY 2 TRIAL? How do I know if I am eligible for the I-SPY 2 TRIAL? What biomarkers will be used to see if I am eligible for the I-SPY 2 TRIAL? What is MammaPrint ® ? What MammaRrint ® score do I need to participate in I-SPY 2? Patients that participate in I-SPY 2 are women that we think will likely benefit from chemotherapy. For this trial, your cancer needs to be one of the following to be eligible: 1)MammaPrint High Risk Score 2)MammaPrint Low Risk Score and ER negative 3)MammaPrint Low Risk Score and ER positive and Her2 positive If your cancer does not match one of the above groups, you will not be eligible to join the I-SPY 2 TRIAL. Please discuss other treatment options with your doctor. Why will I receive treatment before surgery in I-SPY 2? Why will I receive 2 different chemotherapy treatments? If I agree to be in I-SPY 2, how soon will I be able to start my treatment? How likely am I to receive an investigational drug if I join I-SPY 2? If I do receive an investigational drug, who pays for the investigational drug, what will it be, and what are the potential short and long term side effects?

5. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial Cancer Centers Participating in I-SPY 2 Here is a list of Cancer Centers that are enrolling patients in the I-SPY 2 TRIAL: Show Map of US/etc with sites- allow user to click on center’s logo and be directed to their website (either main university site or site’s breast care center site) You can also visit www.breastcancertrials.org to check your eligibility for I-SPY 2 or other clinical trials in your area.www.breastcancertrials.org

6. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial Peer Support for I-SPY 2 Participants A peer support network is available to all I-SPY 2 Participants. Please check with _________ for local services that are available for you. Breast Cancer Network of Strength has a hot-line you can call, 1-800-221-2141, at any time and tell them you would like to speak to an I-SPY 2 counselor. They will take your contact information and arrange to have someone return your call within 48 hours.

7. Home More Information about I-SPY 2 Participating Cancer Centers Peer Support for I-SPY 2 Participants More Information About Breast Cancer I-SPY 2 Breast Cancer Clinical Trial More Information about Breast Cancer To find out more about cancer and breast cancer, please visit the websites listed below. National Cancer Institute (NCI) website www.Cancer.gov NCI Educational Material on Clinical Trials: http://www.cancer.gov/clinicaltrials/learning http://www.cancer.gov/clinicaltrials/learning NCI Dictionary of Cancer Terminology: http://www.cancer.gov/dictionary/