1. IKMG – * International Kidney and Monoclonal Gammopathy Research Group
2nd International Meeting
La Rochelle, France, September 3-4, 2015
Dear Friends and Colleagues,
We would like to invite you to attend the second international IKMG meeting in La Rochelle which is taking place in September The goal of the IKMG is to promote research into, and understanding of, kidney diseases resulting from monoclonal gammopathies and we are very excited about the program our organizing committee has put together. We plan to include state of the art lectures on the pathology, diagnostics and treatment of monoclonal gammopathy-related kidney diseases presented by experts from around the world. A poster and plenary session will cover the latest advances in this evolving field. This meeting will hopefully stimulate exchanges between clinicians and researchers, and open up new perspectives for diagnostic and therapeutic approaches to the treatment of these rare disorders, through a better understanding of their pathophysiological mechanisms. Call for abstracts will be announced in May.
La Rochelle is a very pleasant city located on the west coast of France. The meeting will be held at the Espace Encan, close to the old port in the historical city center, with a wide choice of hotels within walking distance. The social program will be a unique opportunity to discover the best local food.
We look forward to meeting you in La Rochelle,
Guy Touchard, Congress President , Frank Bridoux, Congress Vice-President, Nelson Leung, IKMG President,
Maria M. Picken, IKMG secretary
* ERA-EDTA’s endorsement is for the promotion of education in general, therefore the specific content of the event/course is the responsibility of the organizer
Online Registration and Hotel Reservation:
Contact: Tiffany Barbier, La Rochelle Evenements,
Quai Louis Prunier – BP La Rochelle cedex 01, France
Tel : (33)
address:
Registration fees (including lunch and dinner on Thursday September 3rd): Seniors: 325 Euros
MD or PhD age less than 35 years: 175 Euros
Trainees, PhD students: 75 Euros
The number of participants will be limited to 250, registration will close on Monday August 31, 2015

2. FINAL PROGRAM Thursday, Sept. 3. Financial Sponsors:
8:00 a.m. – 10:00 a.m. Monoclonal gammopathy of renal significance – MGRS
Moderators: Guy Touchard and Robert Kyle
- Introduction: Guy Touchard and Nelson Leung
- The history of monoclonal gammopathies: Robert A. Kyle (Mayo Clinic, Rochester, MN, USA)
Classification of renal disorders in monoclonal gammopathies: Guy Touchard (University of Poitiers, France)
MGRS: an evolving concept: Nelson Leung (Mayo Clinic, Rochester, MN, USA)
- The kidney biopsy in MGRS: recent advances in pathology: Samih Nasr (Mayo Clinic, Rochester, MN, USA)
- Coffee break
10:15 a.m. – 12:30 a.m. Proximal Tubule in Monoclonal Gammopathy: From the microscope to the Lab
Moderators: Pierre Ronco and Maria Picken
- Light chain (LC) tubulopathy with crystals: Vivette D’Agati (Columbia University, New-York, NY, USA)
- LC proximal tubulopathy without crystals: Guillermo A. Herrera (Louisiana State University, Shreveport, LA, USA)
- LC-induced interstitial nephritis: Maria M. Picken (Loyola University Medical Center, Chicago, IL, USA)
- Inflammatory pathways involved in proximal tubular injury: Veichi Batuman (Tulane University, New Orleans, LA, USA)
- Panel discussion
2:00 p.m. – 3:00 p.m. Update on monoclonal protein detection/measurement
Moderators: Helen Lachmann and Arnaud Jaccard
- New free light chain assays: Ashu Wechalekar (National Amyloidosis Centre, London, UK)
- Mass spectrometry: David Murray (Mayo Clinic, Rochester, MN, USA)
3:00 p.m. – 4:00 p.m. New Renal response and emerging therapies in AL amyloidosis
Moderators: Joan Blade and Julian Gillmore
- Assessing renal response in AL amyloidosis: Giampaolo Merlini (University of Pavia, Italy)
- Anti-SAP therapy: Philip Hawkins (National Amyloidosis Centre, London, UK)
4:30 p.m. – 6:00 p.m. Update on the management of myeloma cast nephropathy
Moderators: Jean Paul Fermand and Nelson Leung
- Chemotherapeutic options: Efstathios Kastritis (University of Athens, Athens, Greece)
- Free light chain removal: Colin Hutchison (Hawke's Bay DHB, New Zealand)
- Response measurement: Heinz Ludwig (Wilhelmine Hospital, Vienna, Austria)
- Group discussion
6:00 p.m. Poster viewing (titles and authors listed at the end of the program) and wine reception, dinner to follow
Financial Sponsors:

3. FINAL PROGRAM Friday, Sept. 34
8:30 a.m. – 10:30 a.m. Update in pathophysiology: animal models
Moderators: Michel Cogne and Pierre Aucouturier
- Cast nephropathy: Paul Sanders (University of Birmingham Alabama, Birmingham, AL, USA)
- LC Fanconi syndrome: mouse and cellular studies: Olivier Devuyst (University of Zurich, Switzerland)
- AL amyloidosis: Guillermo A. Herrera (Louisiana State University, Shreveport, LA, USA)
- Randall-type MIDD: Christophe Sirac (University of Limoges, France)
- Coffee break
10:45 a.m. – 12:00 a.m. C3 glomerulopathy and monoclonal gammopathy
Moderators: Vivette D’Agati and Samih Nasr
- C3 GP and monoclonal gammopathy: the disease spectrum: Frank Bridoux (University of Poitiers, France)
- The complement system in C3GP and monoclonal gammopathy: Véronique Frémeaux-Bacchi (HEGP, Paris, France)
12:00 – 12:45: Extra-renal manifestations of monoclonal gammopathy: Jean Paul Fermand (Saint Louis University Hospital, Paris, France)
2:00 p.m. – 4:00 p.m. Oral communications
Moderators: Chris Venner and Giampaolo Merlini
The numbers below correspond to the abstract number in the abstract book
1. Comparison of Freelite and N Latex serum free light chain assays in subjects with end stage renal disease on haemodialysis. Kennard A, Hawley C, Tate J, Klingberg S, Pretorius C, Hutchinson C, Mollee P.
16. At Myeloma Diagnosis, Age and Free Light Chain Level Predict Renal Function and These Factors with Free Light Chain Response Predict Renal Outcome.  Yadav P, Drayson MT, Cook M, Pinney J, Giles H, Aung YS, Cockwell P.
18. Cast nephropathy vs Acute Tubular Necrosis in newly diagnosed Multiple Myeloma: a comparative study.  Sathick IJ, Nasr S, Leung N.
37. Proteomic Analysis of Myeloma Cast Nephropathy by Laser Microdissection Capture Tandem Mass Spectrometry Leung N, Sethi S, Quint P, Madden BJ, Bergen III HR, Kumar R.
32. Efficacy of high-cut off membrane in the treatment of acute renal failure due to myeloma kidney – data from Czech cohort of patients.  Ryšavá R, Lachmanová J, Havrda M, Kielberger L, Orság J.
33. Proximal tubulopathies in patients with monoclonal gammopathies of undetermined significance (MGUS): beyond crystals. Herrera GA, Picken MM.
11. Monoclonal light chains associated with Fanconi syndrome trigger aberrations in the lysosome-autophagy pathway in proximal tubule cells.  Bouteau I, Luciani A, Sirac C, Bridoux F, Devuyst O.
13. Current anti-myeloma therapies improve renal manifestations of monoclonal light-chain proximal tubulopathy. Vignon M, Arreule A, Nasr SH, El-Karoui K, Karras A, Roos-weil D, Royer B, Karlin L, Knebelman B, Asli B, Jaccard A, Bridoux F, Leung N, Fermand JP.
9. Urinary albumin to creatinine ratio in morning void can substitute measurement of proteinuria in 24 h collection in diagnosis and staging of renal AL amyloidosis. Riva E, Basset M, Milani P, Foli A, Palladini G, Merlini G.
8. Outcome of patients with AA or AL amyloidosis admitted in ICU.  Guinault D, Canet E, Lavayssiere L , Huart A, Ribes D, Cointault O, Nogier MB, Roussel M, Bernadet-Monrozies P, Lemiale V, Arnulf B, Attal M, Chauveau D, Azoulay E, Faguer S.
31. Clinicopathologic Correlations in Waldenström’s Macroglobulinemia and related IgM producing B- cell lymphoproliferative disorders: A Case Series of 57 patients with Kidney Biopsies.  Higgins L, Said SM, Nasr SH, Gertz MA, Leung N.

4. 4. Kidney Transplant (KT) in Individuals with Monoclonal B-cell lymphocytosis (MBL) and Chronic Lymphocytic Leukemia (CLL).  Strati P, Gharaibeh KA, Leung N, Cosio F, Call TG, Shanafelt TD.
4:00 p.m. Closing remarks
4:30 p.m. – 5:30 p.m. IKMG board meeting
5:30 p.m. – 7:00 p.m. Public patient conference with the participation of the Fédération nationale d’Aide aux Insuffisants rénaux, Association Française contre l’Amylose, Association Française des Malades du Myélome Multiple
POSTER PRESENTATIONS
The numbers below correspond to the abstract number in the abstract book
2. Bortezomib produces high hematological response rates with prolonged renal survival in monoclonal immunoglobulin deposition disease. Cohen C, Royer B, Javaugue V, Szalat R, El Karoui K, Caulier A, Knebelmann B, Jaccard A, Chevret S, Touchard G, Fermand JP, Arnulf B, Bridoux F.
3. Two cases of crystal storing histiocytosis with kidney involvement. Garderet L, Bender S, Brochériou I, Verpont MC, Fabiani B, Boffa JJ, Aucouturier P.
5. A Case Report of a 64-year-old Male with IgG1κ Monoclonal Deposition and Ultrastructural Striated Structure Mimicking Striated Muscle Bundle. Tsukaguchi H, Joh K
6. Proposal for a Classification of the Glomerular Deposition Diseases. Joh K.
7. LECT2 Amyloidosis: Not just a Hispanic disease. Ramzy J, Mollee P, Kwok F, Gilbertson J,
Hosking P, Fraenkel M, Renaut P, Stewart G, Booth D, Gibbs.
10. Masked AL amyloidosis lambda in fibrillar pseudo-amyloid glomerulonepritis with gamma, kappa and lambda positive deposits associated with gamma1 heavy chain disease… Touchard G, Karras A, Nochy D, Goujon JM, Quellard N, Bruneval P, Debiais C , Bender S, Bridoux F.
Acute efficiency and Paradoxical effects of Targeted Therapy for GlomeruloNephritis MembranoProliferative with non organized deposits of IgG3 kappa. Maurier F, Guerard A, Aymard-Chevrier B, Debiais-Delpech C.

5. 14. Proliferative glomerulonephritis with monoclonal IgA deposition : clinical significance and treatment. Vignon M, Faguer S, Noel LH, Guilbeau C, Hertig A, Francois H, Knebelmann B, Pourrat J, Chauveau D, Goujon JM, Bridoux F, El Karoui K.
15. Light chain proximal tubulopathy (LCPT) with (very) incomplete Fanconi syndrome. Stehlé T, Vignon M, Vidal-Petiot E, Figueres ML, Rabant M, Noël LH, Arnulf B, Flamant M.
17. The Impact of Dialysis-Dependent Acute Kidney Injury on Mortality in Myeloma: Findings from England Hospital Episode Statistics Data Yadav P, Evison F, Sangha J, Aung YS, Ray D, Sharif A, Pinney J, Cook M, Drayson MT, Cockwell P.
19. Title: Cryoglobulinemic glomerulonephritis: A single-center experience. Sathick J, Klobucher T, Cornell LD, Murray DL, Leung N, Nasr SH.
20. Bortezomib-containing regimens for the treatment of AL amyloidosis: Experience at a single Institution. Jimenez-Zepeda V, Duggan P, Neri P, Nizar B.
21. Randall type light and heavy chain deposition disease (LHCDD) : clinical and immunopathological characteristics. Diolez J, Desport E, Javaugue V, Debiais C, Cohen C, Goujon JM, Jaccard A, Touchard G, Bridoux F.
22. Mu and kappa LHCDD : the first case ? Javaugue V, Guillaudeau A, Debiais C, Diolez J, Bender S, Gombert JM, Sirac C, Jaccard A, Goujon JM, Bridoux F. and G. Touchard.
23. Long-term outcome in Glomerulonephritis with Organized Microtubular Monoclonal Deposits (Immunotactoid Glomerulonephritis): a case series of 25 patients. Dufour L, Javaugue V, Fermand JP, l Goujon JM, Touchard G, Bridoux F.
24. Elevated creatinine and monoclonal gammopathy: MGRS or not? That isn’t the first question!
Colombo A, Dosbaa I, Labatut D, Verove C, Sechet A, Moumas E.
25. Alpha Heavy Chain Deposition Disease: a case report Colombo A, Debiais C, Lacombe C, Labatut D, Vérove C, Sechet A, Gombert JM, Goujon JM, Moumas E, Touchard G, Bridoux F.
26. Waldenström macroglobulinemia (WM) with type I cryoglobulinemia, intra-capillary glomerulonephritis (GN) and membranoproliferative glomerulonephritis (MPGN) with organized glomerular deposits and thrombi.
Javaugue V, Debiais C, Plasse F, Delbes S, Bonarek H, Goujon JM, Bridoux F, Touchard G.
27. Multiple myeloma and kidney failure: a rare and unexpected cause Labatut D , Rudelle E, Moumas E, Sechet A, Verove C, Colombo A, Roullet B, Delwail V, Puyade M, Motard C.
28. Diversity of Fanconi syndrome (FS) due to monoclonal immunoglobulin light chain (LC) Livrozet M, Aucouturier P, Callard P, Bender S, I Brocheriou, Ronco P, Buob D, Boffa JJ.
29. Clinical symptoms and molecular investigations in 13 patients with Schnitzler syndrome identified at the single UK centre Rowczenio DM, Trojer H, Baginska A, Gillmore JD, Wechalekar AD, Hawkins PN, Lachmann HJ.
30. About a case: fibrillary glomerulonephritis relapses are closely related to B lymphocytes reconstitution and give new insights of its physiopathology and therapeutical strategies. Leibler C, Matignon M, Kofman T, Remy P, Lang P, Audard V,Grimbert P.
34. Unexpected histological finding of Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Patient With Nephrotic Syndrome , Hypertension and Acute Renal Insufficiency.
Lanoiselelee S , Berrou C, Rabant M , Martinez F, Seret G Babinet F , Laradi A.
35. Myeloma cast nephropathy: a single-centre experience from Australia in the era of novel agents. Ramzy J, Galiabovitch E, Schwarer A, McMahon L, Coughlin P, Fong C, Nedeljkovic M, Hosking P, Hocking J, Rajakumar S,Roberts M, Lee D, Gibbs S.
36. Proliferative glomerunonephritis with monoclonal kappa LC and C3 deposits: local activation of the alternative complement pathway? Cohen C, Hummel A, Rabant M, Bridoux F, Knebelmann B.