1. Pharmaceuticals Industry Research and Development

2. $337 billion market 10% AFRICA AND ASIA ( >2/3 WORLD POPULATION ) 80% US, JAPAN AND EUROPE

3. MARKET SUCCESS (AIDS) MARKET SUCCESS (AIDS) MARKET FAILURE (INFECTIOUS DISEASE) MARKET FAILURE (INFECTIOUS DISEASE)

4. Market Failure 14 million died 1999 of preventable treatable disease 14 million died 1999 of preventable treatable disease Minimal drug development Minimal drug development Exacerbation of multidrug resistance Exacerbation of multidrug resistance

5. Research and Development US food and drug administration 1995 US food and drug administration 1995 3% important 3% important 13% modest potential 13% modest potential 84% little or no potential 84% little or no potential

6. Pfizer (justification) Costs Costs Risks Risks What they do ( as opposed to what they dont do ) What they do ( as opposed to what they dont do )

7. What can be done Global Treaty Global Treaty Green light committee Green light committee

8. Summary current crisis in research and development for neglected diseases is a global market failure and global public policy failure current crisis in research and development for neglected diseases is a global market failure and global public policy failure