1. Chapter 43, Campbell & Reece’s Biology 8th Edition
14-2 Immunology
Chapter 43, Campbell & Reece’s Biology 8th Edition

2. Overview: Reconnaissance Recognition and Response
Pathogen
Barrier Defenses
Immune System
Innate Immunity
Acquired Immunity

4. 43.1: Reliance on Shared Traits of Pathogens
Innate Immunity of Invertebrates
Chitin
Lysozyme
Hemocytes
Phagocytosis
Toll Receptors
Discussion of Disadvantages

6. 43.1 (continued) Innate Immunity of Vertebrates Barrier Defenses
Enzymes pH
Cellular Innate Defenses
Leukocytes
TLR
Neutrophils
Macrophages
Responses Exclusive to Vertebrates
Lymphatic System

9. Eosinophils and Dendritic Cells Antimicrobial Peptides “and” Proteins
Interferons
Complement System
Inflammatory Responses
Histamine
Fever
Septic Shock

11. 43.1 Natural Killer (NK) Cells
Role of Class I MHC receptor
Innate Immune System Evasion by Pathogens

12. 43.2: In acquired immunity, lymphocyte receptors provide pathogen-specific recognition
Lymphocytes (/Leukocytes)
T Cells
B Cells
Cytokines
Acquired Immunity: An Overview

13. 43.2: Antigen Recognition by Lymph/Leucocytes
Antigens and their receptors
B cells and plasma cells
Antibodies/Immunoglobulin
Epitopes

14. Receptors Heavy & Light Chains Variable & Constant Regions
T vs. B cell receptors
Introduction to the MHC

17. The Role of the MHC (Major Histocompatibility Complex
Antigen Presentation
Class I MHC Molecules
Cytotoxic T Cells
Class II MHC Molecules
Antigen presenting cells
Recognition
Properties of the Acquired Immune System

19. Amino acid rearrangement
Review: Figure 17.10, Campbell 8th edition, RNA splicing, etc.
Recombinase

21. Origin of Self-Tolerance
Involvement of Apoptosis

23. Amplifying Lymphocytes by Clonal Selection
Effector and Memory Cells
Clonal Selection
Primary Immune Response
B Cell role
T Cell role
Secondary Immune Response

25. 43.3: Acquired immunity defends against infection of body cells and fluids
Humoral immune response
Cell-mediated immune response

27. Helper T Cells: A response to nearly all antigens

28. Cytotoxic T Cells: A Response to Infected Cells
Cell-mediated
CD8
B Cells: A Response to Extracellular Pathogens
Humoral

31. Antibody Classes IgM: first antibody produced in response to infection
Usually consists of four polypeptide chains
IgM: first antibody produced in response to infection
IgG: most abundant, and can cross a placenta
IgA: found in milk, sweat, and tears
IgD: may function to make some B cells memory cells
IgE: involved in allergic reactions and stimulates release of histamine
Polyclonal Antibodies
Monoclonal Antibodies
Medical Use

33. Role of Antibodies in Immunity

34. Active Immunity Immunization Passive Immunity Cowpox
Accelerated secondary response
Influence on society
International affairs
Side effects
Passive Immunity
IgG
IgA

35. Immune Rejection Blood Groups Tissue/Organ Transplants
Bone Marrow Transplant

36. 43.4: Disruptions in immune system function can elicit or exacerbate disease
Allergens
IgE
Anaphylactic Shock
Autoimmunity
Lupus, Rheumatoid Arthritis, Type 1 Diabetes Mellitus, Multiple Sclerosis
Rh incompatibility
Cancer

37. HIV (Human Immunodeficiency Virus)
Helper T Cells
Use of CD4 protein
Transmission & Effects
AZT
Protease Inhibitor Treatment
Social Implications
Discussion on Rationalized Morality