3. Big Idea

4. Science Standard 7.1.f: Students know that as multicellular organisms develop, their cells differentiate..

5. differentiation: the process by which cells change in structure and become capable of carrying out specialized functions. Stem Cell: Cells that exist all around the body and differentiate throughout life.

6.  As cells differentiate, they become different from one another. They also form groups made of other, similarly specialized cells. These groups then form tissues and organs. Differences in Structure  Multicellular organisms begin their lives as one cell.  Through Mitosis and differentiation the single cell becomes an organism with specialized structures.

7. Differences in Structure  Multicellular organisms begin their lives as one cell.  Through Mitosis and differentiation the single cell becomes an organism with specialized structures. Differences in Function  As cells differentiate in structure, they begin to carry out different functions.

8. Tissues, Organs, and Systems  When cells differentiate, they also become organized. 1) They group into tissues ( muscle tissue) 2) Groups of tissues combine to form organs (stomach of an animal) 3) Systems, such as the digestive system, begin to function as organs and tissues work together

9. Increasingly Specialized Cells  As development continues, more fine-grained differentiation occurs.  Ex: The eye consists of two types of cells that are sensitive to light. Rod cells function in dim light, but cannot detect color. Cone cells detect color, but require light to function.

10.  During development, cells become fixed – or set- in how they will differentiate.  The instructions that will determine what will happen is coded in the DNA in its nucleus.  Differentiation occurs when certain sections of DNA are turned off. The active DNA then guides the development of the cell.  Once a cell’s future has been determined, when and how much it will changes depends on its DNA, its function, and the type of organism.  Some cells differentiate completely during development, others do not change until later.

11.  Once human cells differentiate, they usually lose their ability to become other types of cells.  Ex: a blood cell CANNOT change into a skin cell  Humans do produce cells called STEM CELLS that can differentiate throughout life.  Stem Cells exist all around the body, and respond to specific needs in the body by becoming specialized.  EX: production of red and white blood cells.

12.  Cells differentiate in much of the same way as they do in animals.  Differentiated cells become grouped into tissues that make up the roots, stems, and leaves.  Many plants have the ability to grow throughout their lives. This occurs because many plant cells are NOT fixed in their development.  These cells can undergo rapid cell division and differentiation, increasing the size of the roots and stems.  It can also lead to the growth of new roots.

13. Across Disciplines: Language Arts (cause and effect of Lizard growing a new tail) Patterns: Draw a picture of how Tissue, Organs, and systems differentiate. (hint: cells group into tissues than ?) Question: Write a question and answer it. Different Perspectives: The differences in cell differentiation from an animal cell and plant cell Summary: Write a summary of what you have learned.