1. RESEARCH AND INNOVATION Mr Ken Lavery, Medical Director

2. PHILOSOPHY Holistic approach Translational Clinically led Multidisciplinary Developing Expansion ANNUAL GENERAL MEETING, 29 JULY 2010

3. PARTNERS I QVH Blond McIndoe Research Foundation Brighton and Sussex Medical School University of Brighton ANNUAL GENERAL MEETING, 29 JULY 2010

4. PARTNERS II ANNUAL GENERAL MEETING, 29 JULY 2010

5. INFRASTRUCTURE I ANNUAL GENERAL MEETING, 29 JULY 2010 Clinical Management TranslationalResearch HealthcareOutcomes EducationDevelopment

6. INFRASTRUCTURE II Translational research: from the lab to the patient Healthcare outcomes: supported by Clinical Audit, P.R.O.M.S. (patient reported outcome measures) Educational “give me the boy and I will give you the man” involving the medical students in our work and inspiring them to take it forward to the next step in their turn ANNUAL GENERAL MEETING, 29 JULY 2010

7. QVH MODEL ANNUAL GENERAL MEETING, 29 JULY 2010 Clinician led Clinician led Self funding Self funding University/Charity/Hospital University/Charity/Hospital Clinicians of the future Clinicians of the future Flexible/Proactive Flexible/Proactive Collaborative research Collaborative research Clinical Management TranslationalResearch HealthcareOutcomes EducationDevelopment

8. TRANSLATIONAL RESEARCH Wound biology – pH, in vitro Anti-scarring Pain control Skin graft management Biomaterials – nanofibres, microcarriers carbon Psychology - back to work Sepsis - finger print, immunology ANNUAL GENERAL MEETING, 29 JULY 2010

9. RESEARCH / EDUCATION Clinician involvement Taught courses Progression ANNUAL GENERAL MEETING, 29 JULY 2010 Students IRP BSc Post Graduate MD fellow MRes Burns Fellow Clinical Research Pre consultant

10. QVH MODEL Healthcare outcomes Clinical management - surgical, sepsis, commercial, pharmocokinetics Education and Development ANNUAL GENERAL MEETING, 29 JULY 2010

11. STRENGTHS Clinical + Science Personnel Wide research programme Education Collaborations Patient driven Cycle of research Multi- faceted/disciplinary Facilities Managerial/SHA buy in ANNUAL GENERAL MEETING, 29 JULY 2010

12. CURRENT STATUS Joint grant applications with BMRF Prof. Lawrence-Watts as research consultant for QVH and BMRF Collaborations Medical student IRP’s Research Nurse NIHR links Military links Joint appointments Research links mirror clinical links Wider research portfolio for each member ANNUAL GENERAL MEETING, 29 JULY 2010

13. BENEFITS Local model with logical development Enhance vs create Pump priming - plan to establish Chair Patient driven Self sustaining Develops future clinicians Efficient use of resources ANNUAL GENERAL MEETING, 29 JULY 2010

14. CURRENT ACTIVITY 24 Research projects currently funded and on-going including nationally clinically important work in: – Pain Relief; Paracetomol Study; major study on post-operative pain relief Anaesthetics and Maxillofacial Departments – Patient psychological outcomes after breast surgery reconstruction in both men and women, in collaboration with the University of West of England – Long term outcomes for paediatric burn injury; a major study with already 120 patients recruited – Wound healing and scar management – Limbal Cell Sheets for ocular surface rehabilitation Corneo-plastic department ANNUAL GENERAL MEETING, 29 JULY 2010

15. INNOVATION Development of medical devices the QVH has active liaison with NHS Innovations to develop the commercial aspects and ensure the Trust retains the intellectual property and a prototype of a medical device is now ready for clinical trial Three other innovations are being actively pursued ANNUAL GENERAL MEETING, 29 JULY 2010

16. FUNDING The $64,000 question The Money! Charitable funds The Trust is re-organising its charitable funds to make more money available for Research and Development, recognising that research grants may become more challenging to obtain More flexibility should allow more and larger projects to be self-funded ANNUAL GENERAL MEETING, 29 JULY 2010

17. SUMMARY Research and Development has always been at the core of clinical activity at QVH We “punch well above our weight” in terms of the amount and quality of research that we are produce Major academic units see us as a very important partner in their research endeavours Research keeps our profile high nationally and internationally Its not a “nice to do” its for us a “must do” ANNUAL GENERAL MEETING, 29 JULY 2010