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MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2.

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Presentation on theme: "MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2."— Presentation transcript:

1 MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2

2 Locus coeruleus Substantia nigra

3 Imaging of SN

4 Sasaki et al

5 Effect of MT and SPIR

6 Magnetisation transfer Neuromelanin Neuromelanin Macromolecules = short T2* Macromolecules = short T2* Off resonance radiofrequency pulse Off resonance radiofrequency pulse Transfer of energy from macromolecules Transfer of energy from macromolecules water water ?iron ?iron SPIR SPIR presaturation pulse presaturation pulse hidden MT effect hidden MT effect

7 Method T1 MRI T1 MRI Repetition time 757ms Repetition time 757ms Echo time 9.1ms Echo time 9.1ms Voxel size = 0.47x0.47x2.75mm 3 Voxel size = 0.47x0.47x2.75mm 3 SPIR SPIR 7 healthy volunteers 7 healthy volunteers MT not possible due to SAR limits MT not possible due to SAR limits

8 Results - Substantia nigra

9 Results - Locus coeruleus

10 Conclusion The substantia nigra and locus coeruleus are visible using T1 weighted imaging with SPIR The substantia nigra and locus coeruleus are visible using T1 weighted imaging with SPIR Most likely due to an MT effect Most likely due to an MT effect Sequence is sensitive to neuromelanin Sequence is sensitive to neuromelanin Specificity remains to be tested Specificity remains to be tested

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14 Thanks to… Prof Auer Prof Auer All in Academic Radiology All in Academic Radiology All at Sir Peter Mansfield Magnetic Resonance Centre All at Sir Peter Mansfield Magnetic Resonance Centre Prof Mahida and Prof Hawkey Prof Mahida and Prof Hawkey


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