1. Jack Twersky, MD Medical Director CLC Durham

2.  Memory impairment and at least one of the following  Aphasia  Apraxia  Agnosia  Executive function  Impairment  Decline  Delirium

3.  Common Dementias  Alzheimer Disease  Lewy Body Dementia  Vascular Dementia  Mixed Dementia  Frontotemporal Dementia  Parkinson Disease  Less Common Dementias  Alcohol Related Dementias  Traumatic Brain Injury  Normal Pressure Hydrocephalus*  Brain tumor  Paraneoplastic Syndrome  Cancer Treatment  Huntington Disease  Progressive Supranuclear Palsy

4.  Early stage- gradual memory loss. language errors, impaired IADLs, worsening visual spatial-perception  Middle stage- apraxia, disorientation, impaired judgment  Advanced stage- dependent in ADLs, loss of ability to ambulate and swallow

5.  Dementia  Visual hallucinations  Parkinsonism  Cognitive fluctuations  Dysautonomia  Sleep disorders  Neuroleptic sensitivity

6.  Dementia  Cerebrovascular disease  presence of focal signs on neurologic examination,  evidence of relevant CVD by brain imaging (CT or MRI)  + Relationship between the two onset of dementia within three months following a stroke onset of dementia within three months following a stroke abrupt deterioration in cognitive function or stepwise progression of cognitive deficits. abrupt deterioration in cognitive function or stepwise progression of cognitive deficits.

7.  Insidious onset and gradual progression  Early decline in social interpersonal conduct  Early impairment in regulation of personal conduct  Early emotional blunting  Early loss of insight