1. Dr. Ahmed Fathalla Ibrahim

2. TRANSVERSE SECTION ( T1-L3 )

3. GREY MATTER OF SPINAL CORD DORSAL HORN: contains sensory neuronesDORSAL HORN: contains sensory neurones VENTRAL HORN: contains motor neurones (lower motor neurones):VENTRAL HORN: contains motor neurones (lower motor neurones): 1.Alpha motor neurones: 1.Alpha motor neurones: innervate extrafusal muscle fibers 2.Gamma motor neurones: 2.Gamma motor neurones: innervate intrafusal muscle fibers LATERAL HORN (T1-L3): contains autonomic neuronesLATERAL HORN (T1-L3): contains autonomic neurones

4. LAMINATION OF GREY MATTER

5. NUCLEI

6. NUCLEI OF DORSAL HORN Substantia gelatinosa: Site:Site: tip of dorsal horn, laminae I-III Level:Level: all levels Function: second order neurones for pathway of pain & temperature sensations from the body to sensory cortex (lateral spinothalamic tract)Function: contains second order neurones for pathway of pain & temperature sensations from the body to sensory cortex (lateral spinothalamic tract)

7. NUCLEI OF DORSAL HORN Nucleus proprius: Site:Site: ventral to substantia gelatinosa, laminae IV-V Level:Level: all levels Function: second order neurones for pathway of crude touch sensation from the body to sensory cortex (ventral spinothalamic tract)Function: contains second order neurones for pathway of crude touch sensation from the body to sensory cortex (ventral spinothalamic tract)

8. NUCLEI OF DORSAL HORN Nucleus dorsalis (Clarke’s column): Site:Site: base of dorsal horn, lamina VII Level:Level: C8 – L3 Function: second order neurones for pathway of proprioceptive &exteroceptive sensations to cerebellum (dorsal spinocerebellar tract)Function: contains second order neurones for pathway of proprioceptive &exteroceptive sensations to cerebellum (dorsal spinocerebellar tract)

9. NUCLEI OF VENTRAL HORN Medial group: Site:Site: medial part of ventral horn, lamina VIII Level:Level: all levels Function: axial musclesFunction: contains cell bodies of neurones innervating axial muscles

10. NUCLEI OF VENTRAL HORN Lateral group: Site:Site: lateral part of ventral horn, lamina IX Level:Level: all levels: 1.More prominent in cervical & lumbosacral segments 2.Represented by one nucleus in thoracic segments Function:Function: limbmuscles 1.In cervical & lumbosacral segments: contains cell bodies of neurones innervating limb muscles intercostal muscles 2.In thoracic segments: contains cell bodies of neurones innervating intercostal muscles

11. NUCLEI OF VENTRAL HORN Phrenic nucleus: Site:Site: central part of ventral horn, lamina IX Level:Level: C3 – C5 Function: the diaphragmFunction: contains cell bodies of neurones innervating the diaphragm

12. NUCLEI OF VENTRAL HORN Accessory nucleus: Site:Site: base of ventral horn, lamina IX Level:Level: C1 – C5 Function: sternomastoid & trapeziusFunction: contains cell bodies of neurones innervating sternomastoid & trapezius

13. NUCLEI OF LATERAL HORN Intermediolateral nucleus: Level:Level: T1 – L3 Function: preganglionic sympathetic neuronesFunction: contains preganglionic sympathetic neurones N.B.: the nucleus is present in S2-S4 segments (with no lateral horn) & contains preganglionic parasympathetic neuronesN.B.: the nucleus is present in S2-S4 segments (with no lateral horn) & contains preganglionic parasympathetic neurones

14. WHITE MATTER OF SPINAL CORD DORSAL COLUMN (FUNICULUS)DORSAL COLUMN (FUNICULUS) LATERAL COLUMN (FUNICULUS)LATERAL COLUMN (FUNICULUS) VENTRAL COLUMN (FUNICULUS)VENTRAL COLUMN (FUNICULUS) The white matter is formed of tracts: 1.Ascending 2.Descending 3.Both ascending & descending

15. TRACTS

16. MAIN ASCENDING TRACTS DORSAL COLUMN TRACT: Site: the whole dorsal column medialSite: occupies the whole dorsal column, gracile tract is medial to cuneate tract Level:Level: 1.Gracile tract: 1.Gracile tract: all levels 2.Cuneate tract: 2.Cuneate tract: from T6 to C1 Second order neurones: Gracile & cuneate nuclei in medulla oblongataSecond order neurones: Gracile & cuneate nuclei in medulla oblongata Types of fibers: proprioceptive & discriminative (fine) touch fibersTypes of fibers: proprioceptive & discriminative (fine) touch fibers 1.Gracile tract: lower 1.Gracile tract: from lower half of body 2.Cuneate tract: upper 2.Cuneate tract: from upper half of body Termination: sensory cortexTermination: sensory cortex

17. MAIN ASCENDING TRACTS SPINOTHALAMIC TRACTS: Site:Site: 1.Lateral spinothalamic: lateral 1.Lateral spinothalamic: lateral column 2.Ventral spinothalamic: ventral 2.Ventral spinothalamic: ventral column Level:Level: all levels Second order neurones: Substantia gelatinosa (lateral), nucleus proprius (ventral)Second order neurones: Substantia gelatinosa (lateral), nucleus proprius (ventral) Types of fibers: exteroceptive fibers from bodyTypes of fibers: exteroceptive fibers from body 1.Lateral spinothalamic: pain & temperature 2.Ventral spinothalamic: non discriminative (crude) touch Termination: sensory cortexTermination: sensory cortex

18. MAIN ASCENDING TRACTS SPINOCEREBELLAR (DORSAL & VENTRAL) TRACTS: Site: both tracts are located in lateral columnSite: both tracts are located in lateral column Level:Level: all levels Second order neurones:Second order neurones: 1.Dorsal spinocerebellar: Clarke’s column 2.Ventral spinocerebellar: laminae V-VII Types of fibers: proprioceptive & exteroceptive fibers from bodyTypes of fibers: proprioceptive & exteroceptive fibers from body Termination: cerebellumTermination: cerebellum

19. DESCENDING TRACTS CORTICOSPINAL TRACTS: Site:Site: 1.Lateral corticospinal: lateral 1.Lateral corticospinal: lateral column 2.Vental corticopsinal: ventral 2.Vental corticopsinal: ventral column Level:Level: all levels Origin: motor cortexOrigin: motor cortex Function: voluntary, discrete & fineFunction: control of voluntary, discrete & fine movements, especially those of distal parts of limbs

20. DESCENDING TRACTS RUBROSPINAL TRACT: Site: lateralSite: lateral column, intermingled with lateral corticospinal tract Level:Level: all levels Origin: red nucleus of midbrainOrigin: red nucleus of midbrain Function: excitatory effect over tone of limb flexor musclesFunction: excitatory effect over tone of limb flexor muscles

21. DESCENDING TRACTS TECTOSPINAL TRACT: Site: ventralSite: ventral column Level: in cervical regionLevel: in cervical region Origin: superior colliculus of midbrainOrigin: superior colliculus of midbrain Function: mediates reflex movements in response to visual stimuliFunction: mediates reflex movements in response to visual stimuli

22. DESCENDING TRACTS VESTIBULOSPINAL TRACTS: Site: ventralSite: both tracts are located in ventral column Level: all levelsLevel: all levels Origin:Origin: 1.Lateral vestibulospinal: lateral vestibular nucleus in pons & medulla 2.Medial vestibulospinal: the descending fibers of the medial longitudinal fasciculus 2.Medial vestibulospinal: forms the descending fibers of the medial longitudinal fasciculus Function: control body posture & balanceFunction: control body posture & balance

23. DESCENDING TRACTS RETICULOSPINAL TRACTS: Site: ventralSite: both tracts are located in ventral column Level: all levelsLevel: all levels Origin:Origin: 1.Medial reticulospinal: pontine 1.Medial reticulospinal: pontine reticular formation 2.Lateral reticulospinal: medullary 2.Lateral reticulospinal: medullary reticular formation 3.Function: inhibitory or excitatory effect on muscle tone

24. BOTH ASCENDING & DESCENDING TRACTS FASCICULUS PROPRIUS (INTERSEGMENTAL TRACT): occupies a narrow band immediately peripheral to grey matter, serves for coordination between upper & lower limb muclesFASCICULUS PROPRIUS (INTERSEGMENTAL TRACT): occupies a narrow band immediately peripheral to grey matter, serves for coordination between upper & lower limb mucles LISSAUER’S TRACT: lies superficial to the tip of dorsal horn, by the help of this tract, exteroceptive fibers can establish synaptic contacts over several segments of spinal cordLISSAUER’S TRACT: lies superficial to the tip of dorsal horn, by the help of this tract, exteroceptive fibers can establish synaptic contacts over several segments of spinal cord

25. N.B.: TRACTS

26. ASCENDING: 1.Dorsal column: 1.Dorsal column: contains only dorsal column tracts 2.Ventral column: 2.Ventral column: contains ventral spinothalamic tract 3.Lateral column: 3.Lateral column: contains the rest of tractsDESCENDING: ventral column lateral column 1.All desending tracts are present in ventral column EXCEPT: lateral corticospinal & rubrospinal tracts (present in lateral column) 2.No descending tract present in dorsal column

27. N.B.: TRACTS All ascending tracts have same first order neurones: cells of dorsal root ganglionAll ascending tracts have same first order neurones: cells of dorsal root ganglion All descending tracts have same termination: cells of ventral horn (lower motor neurones)All descending tracts have same termination: cells of ventral horn (lower motor neurones)