Presentation on theme: "Pericarditi, Miocarditi e CMP infiammatorie: cosa c’è di nuovo"— Presentation transcript:
1 Pericarditi, Miocarditi e CMP infiammatorie: cosa c’è di nuovo Pericarditi, Miocarditi e CMP infiammatorie: cosa c’è di nuovo? PericarditiMassimo Imazio, MD, FESCDipartimento di CardiologiaOspedale Maria Vittoria, Torino
30 COPE: COlchicine for acute PEricarditis NNT= 5Corticosteroid therapy:RecurrencesOR 4.3095% CI 1.21 to 15.25; p=0.024Here we can see the main results of the study. The primary end point was the recurrence rate. Colchicine reduced the recurrence rate at 18 months down to 11% and was also able to reduce the symptoms persistence at 72 hours as it can be observed in pts with a gouty attack. Drug withdrawal was recorded in about 8% of cases due to diarrhea. Thus in this study we need to treat 5 pts with colchicine in order to prevent 1 recurrence. In multivariate analysis, corticosteroid therapy was an independent risk factor for recurrences.Drug withdrawalImazio M et al. Circulation 2005; 112(13):
31 Colchicina e recidiveImazio M, Trinchero R Rec Prog Med 2006; 98(5):265-70
32 Colchicina e storia naturale della pericardite recidivante Attack rateRec/pt/monthBrucato A et al. Clin Exp Rheumatol. 2006;24(1): 45-50
33 Colchicine: How does it work? Imazio M, Trinchero R. Future Cardiology 2007; 3: 623
34 Imazio M, Trinchero R. Future Cardiology 2007; 3: 623
35 Colchicina e pericardite: Trials in corso Imazio M et al. JCM 2007; Dic; 8(12):1044-8Imazio M et al. JCM 2007; Oct;8(10):830-4Imazio M et al. JCM 2007; Aug;8(8):613-7.
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