1. PROPOSAL FOR TIME-LINE AND ROAD-MAP OF STEM CELL R&D AND SERVICE AT RSCM/FKUI

2. Optimization of available culture techniques -Stem cell identification and isolation -Stem cell amplification -Stem cell differentiation USING AVAILABLE TECHNIQUES FEASIBLE TO BE PERFORMED IN CURRENTLY AVAILABLE FACILITIES Clinical trial independent to the availability of RSUPNCM clean room facility -Cardiovascular therapy utilizing mesenchymal stem cell from PBMC (Stem Cell isolation protocol should be subjected to evaluation by biosafety/patient safety committee) -Bone marrow stem cell/chondrocytes therapy for generation of cartilage CLINICAL APPLICATION ARM LABORATORY RESEARCH ARM I IIIIIIVV Submission and Evaluation of proposals Design and construction of facilities, Establishment of Administration and Managerial System, Legal System, Ethical Guidelines Utilization of Research Facilities (including animal facilities) and Service Facilities for Cord Blood Banking Utilization of Service facilities for Clinical Trial Utilization of Service facilities for patient service

3. -Cardiovascular therapy utilizing mesenchymal stem cell from PBMC (Stem Cell isolation protocol should be subjected to evaluation by biosafety/patient safety committee) -Bone marrow stem cell/chondrocytes therapy for generation of cartilage Optimization of available culture techniques -Stem cell identification and isolation -Stem cell amplification -Stem cell differentiation USING AVAILABLE TECHNIQUES FEASIBLE TO BE PERFORMED IN CURRENTLY AVAILABLE FACILITIES Clinical trial independent to the availability of RSUPNCM clean room facility Optimization of Patented Techniques for Patient Service and Establishment of GMP and GCP -Optimization and Establishment of patented techniques: -Amplification (laboratory) -Stem Cell Delivery (clinical) -Establishment of systems for implementation of GLP, GMP and GCP:Lab, Clinic, Administration,n Managerial, Legal, Etc. Amplification studies Differentiation studies Cancer stem cell studies -R&D in amplification of adult Stem Cell (including generation and amplification of induced pluripotent stem cells) -R&D in differentiation into various tissues -R&D in cancer stem cell (role in cancer pathogenesis, development of diagnostic and theurapeutic system) CLINICAL APPLICATION ARM LABORATORY RESEARCH ARM I IIIIIIVV Submission and Evaluation of proposals Design and construction of facilities, Establishment of Administration and Managerial System, Legal System, Ethical Guidelines Utilization of Research Facilities (including animal facilities) and Service Facilities for Cord Blood Banking Utilization of Service facilities for Clinical Trial Utilization of Service facilities for patient service

4. -Optimization and Establishment of patented techniques: -Amplification (laboratory) -Stem Cell Delivery (clinical) -Establishment of systems for implementation of GLP, GMP and GCP:Lab, Clinic, Administration,n Managerial, Legal, Etc. Optimization of available culture techniques -Stem cell identification and isolation -Stem cell amplification -Stem cell differentiation USING AVAILABLE TECHNIQUES FEASIBLE TO BE PERFORMED IN CURRENTLY AVAILABLE FACILITIES Clinical trial independent to the availability of RSUPNCM clean room facility Optimization of Patented Techniques for Patient Service and Establishment of GMP and GCP Amplification studies Differentiation studies Cancer stem cell studies -R&D in amplification of adult Stem Cell (including generation and amplification of induced pluripotent stem cells) -R&D in differentiation into various tissues -R&D in cancer stem cell (role in cancer pathogenesis, development of diagnostic and theurapeutic system) Scaffold Design and Utilization of Animal Models Safety and Efficacy Studies Exploration of stem cell utility for other purposes: -Pharmacogenomic/genetic studies -Immunopathogenesis and infection studies Aplication of patented techniques for Clinical Trial and banking service -Banking -Autologous Adult Stem Cell -Cord Blood? -Application of patented Stem Cell Sorting and Amplification for clinical trial -Clinical Trial of Patented Stem Cell Therapy: -Safety Evaluation -Efficacy CLINICAL APPLICATION ARM LABORATORY RESEARCH ARM I IIIIIIVV Submission and Evaluation of proposals Design and construction of facilities, Establishment of Administration and Managerial System, Legal System, Ethical Guidelines Utilization of Research Facilities (including animal facilities) and Service Facilities for Cord Blood Banking Utilization of Service facilities for Clinical Trial Utilization of Service facilities for patient service

5. Optimization of available culture techniques -Stem cell identification and isolation -Stem cell amplification -Stem cell differentiation USING AVAILABLE TECHNIQUES FEASIBLE TO BE PERFORMED IN CURRENTLY AVAILABLE FACILITIES Clinical trial independent to the availability of RSUPNCM clean room facility Optimization of Patented Techniques for Patient Service and Establishment of GMP and GCP Amplification studies Differentiation studies Cancer stem cell studies -R&D in amplification of adult Stem Cell (including generation and amplification of induced pluripotent stem cells) -R&D in differentiation into various tissues -R&D in cancer stem cell (role in cancer pathogenesis, development of diagnostic and theurapeutic system) Scaffold Design and Utilization of Animal Models Safety and Efficacy Studies Exploration of stem cell utility for other purposes: -Pharmacogenomic/genetic studies -Immunopathogenesis and infection studies Aplication of patented techniques for Clinical Trial and banking service -Cardiovascular -Cartilage and Bone -Neurologic disorder -Etc. CLINICAL APPLICATION ARM LABORATORY RESEARCH ARM I IIIIIIVV Submission and Evaluation of proposals Design and construction of facilities, Establishment of Administration and Managerial System, Legal System, Ethical Guidelines Utilization of Research Facilities (including animal facilities) and Service Facilities for Cord Blood Banking Utilization of Service facilities for Clinical Trial Utilization of Service facilities for patient service Use of Service Facilities for Patient Service/Clinical Trials