1. Ki Cheol Chang, MD 1, 2, Mee Kum Kim, MD 1, 2, Won Ryang Wee, MD 1,2, Jin Hak Lee, MD 2,3, Beom Seok Jeon, MD 4 Department of Ophthalmology, Seoul National University College of Medicine 1, Artificial Eye center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea 2, Department of Ophthalmology, Bundang Seoul National University Hospital 3, Department of Neurology, Seoul National University College of Medicine 4 Effect of Dose-Dependent Application of Amantadine on Corneal Endothelium

2. Amantadine – related Corneal Toxicity Mechanism : unknown Idiosyncratic hypersensitivity ? or Dose – dependent ?

3. Purpose : To verify if amantadine has dose–dependent toxicity on the corneal endothelium in addition to idiosyncratic hypersensitivity by investigate central corneal thickness (CCT) and corneal endothelial status such as endothelial cell density (EDC), coefficient of variation (CoV) and hexagonality (% Hex) of the Parkinson’s subjectsbtaking amantadine