1. How to promote entrepreneurship and commercialization of research at an old General University? Lars Jonsson Head of UU Innovation & UUAB Holding Company Uppsala University Sweden

2. Old General Universities Difficult to grasp Even more difficult to manage Long processes to achieve living policies Strong academic culture –It is not noble to commercialize –Professor's privilege

3. Uppsala University 530 years in business… –Strong academic traditions –Academic research should stand free! Heavily decentralized Strongly divested –Theology  Space Technology

4. Arts & Social Sciences Nine faculties, Three disciplinary domains Arts Educational Sciences Languages Law Social Sciences Theology Medicine Pharmacy Science and Technology

5. Professor's privilege A Swedish specialty… All results are the researchers private equity –The University has no rights –Only Sweden; (Italy with some restrictions) Can not use University Money for –Patent applications –Investments in shares –Investments in developing projects

6. Tough odds for patents! Canadian survey »Thomas Asterbot, Univ of Toronto, 2003 1061 out of 1091 failed…. < 7 % reached the market 0,5 % became profitable

7. Research is an investment Return of investment: –Competitive work force –Competitive inventions –Knowledge based economy –Increased welfare A University Innovation System is mandatory to achieve this !

8. Commercialize research We have a mission to make our research useful to society through commercialization and patents. Anders Hallberg, Vice-Chancellor, Uppsala University, 2006

9. Patents are instruments Patents and Knowledge Transfer should not be the goal for a university institution They are tools to establish a relation and enforce the institution!

10. The Svedberg –Nobel Laureate 1926 –The Ultracentrifuge Arne Tiselius –Nobel Laureate 1949 –Electrophoresis and Chromatography –Gel filtration, phase partition etc Today: GE Health Biosciences ”The Svedberg Group” - the cradle of modern biotechnology industry!

11. Uppsala Bio Invention to company turn-over 200019601940 Pharmacia Biotech   GE Healthcare 600 MUSD * Electrophoresis Dextran IgE Phadia 204 MUSD 1980 neuropeptides effect on ocular blood flow Xalatan™ 1.300 MUSD SPR Biosensors Biacore 67 MUSD AMO Uppsala 114 MUSD Function of Hyaluronic acid Q-Med 78 MUSD Heparin Fragmin™ Biotage Microwave syntheses Padlock Probes Olink Research inventions Commercialization Turn-over today ~2,600 MUSD / year of which > 1,000 MUSD is based in Uppsala

12. What have been done - Organizational structure 19851990199520002005 Liasion office STUNS – Non-profit university & society foundation Science Park UUAB Holding Company Technical Bridge Foundations Ad hoc Collaboaration And spin-outs

13. Owned by the University Arm length distance – no part of the Authority Legal form = private company The Government decides the object in the Articles of Associations UUAB The Holding Company of Uppsala University

14. What have been done - Organizational structure 19851990199520002005 Liasion office STUNS – Non-profit university & society foundation Science Park UUAB Holding Company CEF Entrepreneurial Educational Programs Patent Office Connect PUB meetings University Liasion Company Venture Cup UU Innovation A Wall Chair Key Actors Program ÅMA Material Academy Technical Bridge Foundations Ad hoc Collaboaration And spin-outs SHB Patent Grants Foundation UIC Business Incubator Innoventus Life Science Venture Drivhuset Student Foundation

15. What have been done - Processes Recruiting right people Two-cultural Identify champions and relate Researchers External network of entrepreneurs Traditional spin-out strategy Start-ups, out licensing Collaborative research Pro active approach

16. Three main processes Stimulate entrepreneurship –Mainly students –Business idea in a known market Commercialization of inventions –Research results, new products & markets Creation of business opportunities –Collaborative research platforms –between disciplines and with companies

17. Stimulate 1 CEF - Centre for Entrepreneurship University centre to stimulate entrepreneurship –The School of Entrepreneurship Last year program for science students Real industrial project + theory & seminaries –Project Management for students –Seminaries for PhD students and researchers –Seminaries for small knowledge based companies

18. Stimulate 2 Drivhuset Student non-profit organization –Inspire and stimulate students –Support entrepreneurship vs employed –Seminaries, lectures and hands on –50 student based companies per year

19. Stimulate 3 Anders Wall's chair Professor chair in entrepreneurship –Donation by Anders Wall, famous local entrepreneur –Education and research –Entrepreneurial Day Entrepreneurs Academy Niklas Zennström, founder of Skype –Dollar billionair, Uppsala alumni

20. Top Class International Research Find FosterForward Secure Verify Develope UIC- Business Incubator Start-Ups Existing Company Free Patent Supervisor ~ 150 discl/year Projects (UUAB) New Company Innoventus Existing Company Fuel Professional Project Management UUAB $ UUAB $ UUAB $ $ $ $ VC $$$ Commercialization of research results Disclosure process

21. Business Incubator UIC We are business developers, not landlords Business coach 1 day / week –Not for free, but pay when (if) you can UIC not an owner! Gives 7,9 times return on the tax investment!

22. UUAB the Holding Company > 500 disclosures > 50 start-ups Invested ~ 8 M€ High value creation + 63 MSEK already realized

23. UUAB Results (june 2007) UUAB Invested 7,8 M€ Realized profit UUAB (exits) 6,7 M€ Value of portfolio ~ 7,7 M€ Running costs 3,3 M€ Net profit ~ 3,3 M€ Consequently investments ~ 128 M€ Generated University Incomes ~ 26 M€ Huge leverage for the University and the Society

24. Commercialization units Uppsala University A new entity UU Innovation Faculty & Departments UU Innovation Strategy Partnership IPR management Business Law Entrepreneurship Innovation Vice-Chancellor (President) Vice President UUAB (Holding Company) Forskarpatent (Patent Office) Uppsala Innovation Centre business incubator One Manager

25. Society - the winner Not always profitable for the professor for the university for the Holding Company Very profitable for the society Gives valuable collaborations Increases the competitiveness of the university

26. Never ever give up “Success is going from failure to failure without a loss of enthusiasm”- Winston Churchill