2. The Nervous System Functions, Structures and the Classification of Neurons http://www.alz.org/brain/01.asp

3. FEATURES Composed of unique tissue which is both responsive and conductive (messages can travel at least 200 mph) Pinpoint control (targets specific tissues in body) The most intricately organized matter on Earth (1cm 3 Brain = Several million neurons)

4. Organs of the Nervous System Central Nervous System (CNS) –Brain & Spinal Cord Peripheral Nervous System (PNS) –Cranial Nerves & Spinal Nerves

5. CNS PNS Sensory (afferent neurons) *incoming messages to CNS *senses external and internal environment Motor (efferent neurons) *messages from CNS to muscle or glands Autonomic Somatic SympatheticParasympathetic Nervous System Effectors: skeletal muscles: conscious control Effectors: smooth muscles, cardiac, glands: unconscious control *Maintains homeostasis: self-maintenance fxns (calming affect) *NT: AcH *fight or flight Arousal or energy generation Increase heart &respiratory rate *NT: norepinephrine

8. Structural Classification 1.Multipolar a.Many processes/extensions but only one is an AXON b.Abundant in CNS 2.Bipolar a.? Extensions; one is still the axon b.Abundant in eyes, nose and ears 3.Unipolar a.? Extension; forms central and peripheral processes

12. General Functions of the Nervous System 1.Sensory 2.Integrative 3.Motor

13. FUNCTIONS Sensory Input - Conduction of signals from receptors to integration center (eyes) Integration - Process by which info. from environment is interpreted & associated with appropriate response of the body –Most occurs in CNS (brain & spinal cord) Motor Output - Conduction of signals from CNS to effector cells (muscles or glands) that actually carry out response to stimulus

14. Integrative Function CNS Type of neuron it occurs in: interneuron Stimulated by: NT-neurtotransmitter –Released by a sensory neuron Receptive portion: dendrites Involves interpretation of an incoming sensory impulse Begins a motor impulse from dendrites down axon into terminal end of the axon

15. Sensory Input Function PNS Type of neuron: sensory neuron (afferent) Sensory Receptors(receptive portion) detect changes occurring in their surroundings at end of dendrites Stimulated by: light, temp change, etc –Once stimulated, sensory receptors transmits a sensory impulse to the CNS Sensory impulse is carried on a sensory neuron from dendrites through cell body down axon to synaptic knobs

16. Motor Function PNS Type of neuron it occurs in: motor neuron (efferent) –involves the response of a body part Motor impulses are carried from CNS to responsive body parts called effectors Stimulated by: NT released by interneurons Effectors –Muscles (contract) –Glands (secrete a hormone)

17. Cells of the Nervous System There are 2 main classes of cells: A. Neurons - conduct messages Common Features –Cell body (contains nucleus & other organelles…no centrioles???) –Dendrites (conveys signal to cell body) –Axons (conduct messages away from cell body) –Myelin Sheath (insulation layer composed of Schwann Cells) –Synaptic Terminal (relays signals to other cells by releasing neurotransmitters) –Synapse (site of contact between terminal & target cell) –Nodes of Ranvier (gaps in myelin, voltage channels)

18. B. Supporting Cells - protects, insulates, and assists neurons (Outnumber neurons 10-50 times) Do not conduct impulses, but are essential for the integrity of nervous system Supporting Cells are called “Glial Cells” (glue) Several Types 1.Astrocytes - encircles capillaries in brain, restricts passage of substances into brain 2.Oligodendrocytes - form insulating myelin sheaths around axons in neurons of CNS 3. Schwann Cells - form insulating myelin sheaths around axons in neurons of Peripheral nervous system –Myelin Sheaths - jelly roll composed of lipid (poor conductor) –Multiple Sclerosis = degenerative disease of myelin sheaths (What symptoms would you expect to see?)

19. Histology of the Neuron 1. Cell Body 2. Dentrites 3. Axon a.One per neuron b.Long, thin processes with uniform diameter c. carry impulses away from cell body d.Many fine extensions at end called collaterals e.Axon ending= at ends of collaterals contain synaptic knob (comes in contact with receptive surface of another cell)

20. Histology of the Neuron Different types of Axons 1.Axons in PNS a.Large and surrounded by myelin sheath (made of lipids) b.Contains Schwann Cells i.Myelinated nerve fibers/ produce the myelin ii.Between each Schwann cell is a space called Nodes of Ranvier 2.Small axons a.Lack myelin sheath b.However all axons are associated with Schwann cells

21. Histology of the Neuron 3.Axons in CNS a.Myelin is produced by oligodendrocyte NOT schwann cells b.Myelinated nerve bundles are referred to as white matter c.Gray matter a.Unmyelinated nerve fibers

22. Histology of the Neuron Regeneration of Nerve Fibers 1.Injury to cell body: dead neuron 2.Injury to axon: possible regeneration

23. Histology of the Neuron Neuroglial Cells accessory cells of the nervous system form the supporting network for neurons (nerve glue) 1PNS= Schwann 2CNS= 4 types Oligodendrocytes oLooks like an eye balls; produces myeline Astrocytes oNourishes neurons Microglia oLooks like spider; phagoctosis Ependyal cells oEpithelial like layer oFunctions to line spaces in CNS

24. Classification of the Neuron Neurons of classified based on –Function –Structure

25. Functional Classification 1.Sensory neurons a.PNS b.Afferent neurons: carry sensory impulses from sensory receptors to CNS c.Location: skin and sense organs 2.Interneurons a.CNS b.Links other neurons together c.“Association” 3.Motor a.PNS b.Efferent neurons; carry motor impulses away fron CNS and to effectors c.Effectors: muscles and glands (involuntary and voluntary controls)