1. Tuberculosis in England 2015 report (presenting data to end of 2014) Tables and figures slide set

2. 2 TB case notifications and rates, England, 2000-2014 Tuberculosis in England: 2015 report I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Office for National Statistics (ONS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

3. 3 Tuberculosis in England: 2015 report Three-year average TB rates by local authority district, England, 2012-2014 Contains Ordnance Survey data © Crown copyright and database right 2015. Contains National Statistics data © Crown copyright and database right 2015. London Source: Enhanced Tuberculosis Surveillance (ETS), Office for National Statistics (ONS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

4. 4Tuberculosis in England: 2015 report Contains Ordnance Survey data © Crown copyright and database right 2015 North West (646) North East, Yorkshire & the Humber (692) East Midlands (399) West Midlands (782) South East & South West (991) East of England (438) London (2,572) * The TB Control Boards (TBCBs) are aligned with PHEC boundaries other than North East and the Yorkshire and the Humber PHECs, which together form the North East, Yorkshire and Humber TBCB, and the South East and South West PHECs, which together form the South East and South West TBCB Number of TB case notifications by TB control board*, England, 2014 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

5. 5 TB case notifications and rates by PHE Centre, England, 2014 Tuberculosis in England: 2015 report I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Office for National Statistics (ONS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

6. 6 TB case notifications and rates by place of birth, England, 2000-2014 Tuberculosis in England: 2015 report I 95% CI (too narrow to be visible) I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Labour Force Survey (LFS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

7. 7 TB case notifications and rates by age group and place of birth, England, 2014 Tuberculosis in England: 2015 report I 95% CI (too narrow to be visible) I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Labour Force Survey (LFS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

8. 8 Country of birth and time from UK entry to TB notification, England, 2014 Tuberculosis in England: 2015 report Country of birth Number of cases Percentage of cases (%)* Median time in years since entry to UK (IQR) UK1,77428.2 - India1,28820.57 (3 - 14) Pakistan79112.610 (3 - 25) Somalia2303.710 (3 - 14) Bangladesh2073.38 (4 - 19) Nepal1682.74 (3 - 9) Nigeria1181.97 (2 - 17) Philippines1111.89 (4 - 13) Zimbabwe1071.711 (9 - 12) Afghanistan961.58 (4 - 13) Romania881.41 (0 - 6) Eritrea831.33 (0 - 8) Kenya811.319 (8 - 41) Sri Lanka781.211 (4 - 15) Poland701.16 (2 - 8) Others (each <1%)1,00715.88 (3 -16) Total*6,297 100.0 9 (3 - 20) * Where country of birth was known Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

9. Trend in TB case notifications for top five countries of birth* of non-UK born cases, England, 2005-2014 9Tuberculosis in England: 2015 report * Five most frequent countries of birth in 2014 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

10. 10 Time between entry to the UK & TB notification for non-UK born cases by year, England, 2005-2014 Tuberculosis in England: 2015 report Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

11. 11 TB case notifications and rates by place of birth and ethnic group, England, 2014 Tuberculosis in England: 2015 report I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Labour Force Survey (LFS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

12. Trend of TB case notifications by age group and ethnic group* in UK born cases, England, 2000-2014 12Tuberculosis in England: 2015 report * Cases with Black-Caribbean, Black-African, Black-Other, Indian, Pakistani, Bangladeshi, Chinese and Mixed/Other ethnic groups were grouped as ‘non-White’ Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

13. 13 TB case notifications by site of disease, England, 2014 Tuberculosis in England: 2015 report * With or without disease at another site ** Total percentage exceeds 100% due to disease at more than one site CNS - Central Nervous System Site of disease*Number of casesPercentage** Pulmonary3,43452.9 Extra-thoracic lymph nodes1,44522.3 Intra-thoracic lymph nodes86313.3 Unknown extra-pulmonary6389.8 Pleural5668.7 Other extra-pulmonary5047.8 Gastrointestinal3685.7 Bone – spine3104.8 Miliary1792.8 Bone – not spine1682.6 CNS – meningitis1482.3 Genitourinary1292.0 CNS – other991.5 Cryptic disseminated390.6 Laryngeal160.2 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

14. 14Tuberculosis in England: 2015 report Rate of TB in UK born children (0-14 years old), England, 2000-2014 I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Office for National Statistics (ONS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

15. 15Tuberculosis in England: 2015 report Number and proportion of cases with unique and clustered MIRU-VNTR strain types, England, 2010-2014 * Clustered in time period (2010-2014), clustered cases notified in year ** A new cluster forms at the point when a second case is notified with the same MIRU-VNTR strain type as an existing case Year Notified cases Culture confirmed cases Strain typed cases (≥23 loci) Unique casesClustered cases * New clusters (per year) ** nn%n%n%n%n 20107,6774,60960.03,22970.11,39143.11,83856.9366 20118,2765,02960.84,26784.81,84643.32,42156.7536 20128,0864,89560.54,30187.91,75440.82,54759.2534 20137,2574,39060.53,65683.31,52641.72,13058.3401 20146,5203,91460.03,31984.81,51245.61,80754.4408 Total37,81622,83760.418,77282.28,02942.810,74357.22,245 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

16. 16Tuberculosis in England: 2015 report Proportion of MIRU-VNTR clusters by size, England, 2010-2014 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

17. Number and proportion of pulmonary TB cases by delay from symptom onset to treatment start, England, 2011-2014 17Tuberculosis in England: 2015 report Year 0-2 months2-4 months>4 monthsTotal* n%n%n%n 20111,31745.085629.375325.72,926 20121,36944.092529.881426.23,108 20131,22241.290030.484128.42,963 20141,13739.586830.287030.32,875 * The number of pulmonary cases with time between onset of symptoms to start of TB treatment available, excluding those diagnosed post-mortem and those that were known to not start treatment Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

18. Proportion of pulmonary cases with a delay from symptom onset to treatment start of >4 months by age group, England, 2011-2014 18Tuberculosis in England: 2015 report Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

19. Proportion of cases with a delay from symptom onset to treatment start by place of birth, England, 2011-2014 19Tuberculosis in England: 2015 report Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

20. 20 TB outcome at 12 months for drug sensitive cases with expected treatment duration <12 months*, England, 2013 * Excludes initial and amplified to rifampicin resistant TB and MDR-TB cases and MDR-TB treated cases and those with CNS, spinal, miliary or cryptic disseminated TB ** Not evaluated includes missing, unknown and transferred out Tuberculosis in England: 2015 report n = 6,422 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

21. 21Tuberculosis in England: 2015 report Treatment completion at 12 months for drug sensitive TB cases with expected treatment duration <12 months*, England, 2004-2013 * Excludes initial and amplified to rifampicin resistant TB and MDR-TB cases and MDR-TB treated cases and those with CNS, spinal, miliary or cryptic disseminated TB I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

22. 22 Last recorded TB outcome for drug sensitive cohort with CNS, spinal, miliary or cryptic disseminated* TB, England, 2013 * Excludes initial and amplified to rifampicin resistant TB and MDR-TB cases and MDR-TB treatment cases and only includes drug sensitive TB cases with CNS, spinal, military or cryptic disseminated TB ** Not evaluated includes missing, unknown and transferred out Tuberculosis in England: 2015 report n = 751 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

23. 23Tuberculosis in England: 2015 report Number and proportion of TB cases with initial drug resistance, England, 2005-2014 * Culture confirmed cases with DST results for at least isoniazid and rifampicin resistant to isoniazid without MDR-TB ** Culture confirmed cases with DST results for at least isoniazid and rifampicin resistant to rifampicin, including those with MDR-TB I 95% CI I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

24. 24Tuberculosis in England: 2015 report Number and proportion of TB cases with drug resistance by age group, England, 2014 * Culture confirmed cases with DST results for at least isoniazid and rifampicin who are resistant to isoniazid without MDR-TB ** Culture confirmed cases with DST results for at least isoniazid and rifampicin who are resistant to rifampicin, including those with MDR-TB # All culture confirmed cases with DST results for at least isoniazid and rifampicin $ Three cases aged 25-34 and one case aged 35-44 were resistant to rifampicin without MDR-TB Age group (years) Resistant to isoniazid without MDR-TB cases* MDR/RR-TB cases** Total cases # n%n%n 0-400.00 12 5-1424.300.046 15-24315.691.6558 25-34625.724 $ 2.21,088 35-44516.811 $ 1.5746 45-54336.371.3525 55-64205.941.2339 65+162.810.2575 Total2155.5561.43,889 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

25. 25Tuberculosis in England: 2015 report Most frequent countries of birth of TB cases with drug resistance, England, 2014 * Top 14 countries of birth for cases resistant to isoniazid without MDR and MDR/RR-TB cases in 2014. ** Culture confirmed cases with DST results for at least isoniazid and rifampicin # Culture confirmed cases with DST results for at least isoniazid and rifampicin who are resistant to isoniazid without MDR-TB $ Culture confirmed cases with DST results for at least isoniazid and rifampicin who are resistant to rifampicin, including those with MDR-TB ^ Two cases from Nigeria and one case from India were resistant to rifampicin without MDR-TB Country of birth* Total cases** Resistant to isoniazid without MDR-TB cases # MDR/RR-TB cases $ nn%n% UK967525.460.6 India780405.110^1.3 Pakistan469275.830.6 Somalia129107.800.0 Philippines7579.322.7 Afghanistan59711.911.7 Bangladesh10776.500.0 Nepal11365.321.8 Lithuania46510.91123.9 Eritrea5359.400.0 Nigeria8144.93^3.7 Zimbabwe6922.934.3 Ethiopia2713.7311.1 Latvia1516.7320.0 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

26. 26Tuberculosis in England: 2015 report TB outcome at 24 months for drug resistant cohort, England, 2012* * Includes initial and amplified MDR/RR-TB and MDR-TB treatment cases only ** Not evaluated includes missing, unknown and transferred out n = 94 Last recorded TB outcome for entire drug resistant cohort, England, 2012* n = 94 Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

27. 27Tuberculosis in England: 2015 report Treatment completion for drug resistant TB cases, England, 2004-2012* * Includes initial and amplified MDR/RR-TB and MDR-TB treatment cases only Data labels display the number of cases completing treatment I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

28. Proportion of TB cases with a social risk factor by place of birth, England, 2014 28Tuberculosis in England: 2015 report Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

29. Last recorded TB outcome for entire drug sensitive cohort by social risk factor*, England, 2013 29Tuberculosis in England: 2015 report n = 523n = 5,225 * Excludes initial and amplified to rifampicin resistant TB and MDR-TB cases and MDR-TB treated cases and those with CNS, spinal, miliary or cryptic disseminated TB ** Not evaluated includes missing, unknown and transferred out Source: Enhanced Tuberculosis Surveillance (ETS) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

30. 30Tuberculosis in England: 2015 report Rate of TB by deprivation decile, England, 2014 I 95% CI Source: Enhanced Tuberculosis Surveillance (ETS), Index of Multiple Deprivation (IMD 2010) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

31. HIV testing in notified TB cases by age group, England, 2014 31Tuberculosis in England: 2015 report *Proportion is calculated from cases with previous unknown HIV status at TB notification Source: Enhanced Tuberculosis Surveillance (ETS), Survey of prevalent HIV infections diagnosed (SOPHID), HIV & AIDS new diagnoses database (HANDD) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

32. 32Tuberculosis in England: 2015 report Number and proportion of TB cases with HIV co-infection, England, 2001-2013 * Proportion calculated using the number of TB cases (notified TB cases plus all not notified TB isolates) matched to HIV cases as the numerator, and the number of TB cases (notified TB cases plus all not notified TB isolates matched to HIV cases) as the denominator Source: Enhanced Tuberculosis Surveillance (ETS), Survey of prevalent HIV infections diagnosed (SOPHID), HIV & AIDS new diagnoses database (HANDD) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

33. Number of TB-HIV co-infected case notifications by age group*, England, 2001-2013 33Tuberculosis in England: 2015 report * Data for children < 15 years not available Source: Enhanced Tuberculosis Surveillance (ETS), Survey of prevalent HIV infections diagnosed (SOPHID), HIV & AIDS new diagnoses database (HANDD) Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England

34. Number and rate of TB cases detected in high incidence countries through the UK pre-entry screening programme, 2006 to 2014* 34Tuberculosis in England: 2015 report * For countries which only became part of pre-entry screening during the global roll out in 2012-13, there is a possibility of under-ascertainment as clinics were establishing reporting systems during this transition phase ** As of June 2015, 665 sputum samples are pending and the rate may increase when final results are available I 95% CI Source: UK TB pre-entry screening data Data extracted: March 2015. Prepared by: TB Section, National Infection Service, Public Health England