1. News You Can Use… Pete Koval, PharmD Tiffany Wong, PharmD Candidate Cone Health Family Medicine June 2014

2. New Drug Approval Zontivity (vorapaxar) was approved for use in pt’s with history of MI or established PAD Zontivity is an anti-platelet agent & the first in a new class: protease-activated receptor-1 (PAR-1) antagonist 5/8/2014 FDA News & Events

3. Starting Dose Change The starting dose of Lunesta (eszopiclone) has decreased to 1mg (from 2mg) by the FDA due to risk of impairment the morning after use 5/15/2014 FDA News & Events

4. New Drug Approval Entyvio (vedolizumab) was approved for the treatment of moderate to severe ulcerative colitis and moderate to severe Crohn‘s disease 5/20/2014 FDA News & Events

5. New Screening Approval The first HPV DNA test has been approved for primary cervical cancer screening Uses sample of cervical cells; test identifies HPV 16 and HPV 18, while concurrently detecting 12 other types of high-risk HPVs. For women 25 or older 4/28/2014 FDA News & Events

6. Newly Added to Discount List Cozaar (losartan) 50mg was added to K-mart’s discount drug list (#30 = $10) The first ARB added to a discount program There are currently 4 generic ARBs: Losartan (Cozaar) Irbesartan (Avapro) Candesartan (Atacand) Eprosartan (Teveten) 5/27/2014 K-mart Discount Drug List

7. New Drug Approval Evzio® (naloxone) is now available as a new hand-held auto-injector Naloxone is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose May be given to patients at high-risk of an opioid overdose OR their family members/caregivers. 5/6/2014 Partnership for Community Care Pharmacy Newsletter

8. New OTC Approval Nexium 24HR® (esomeprazole 20mg) has now been approved as an OTC medication Use: treatment of frequent heartburn 4/9/2014 FDA News & Events

9. New Drug Approval Natesto® Nasal Gel (testosterone) has been approved as the first nasal testosterone replacement therapy Dose: 2 pumps (one per nostril) three times daily. Total = 33 mg 5/6/2014 Partnership for Community Care Pharmacy Newsletter

10. Generic Approval Celecoxib (celebrex) has been approved as a generic COX-2 inhibitor Capsules: 50, 100, 200, and 400 mg 5/30/2014 FDA News