1. News You Can Use… Lauren Gray, PharmD Candidate February 2015

2. New Drug Approval Bellafill® received FDA approval for the treatment of patients > 21 years of age with: moderate to severe atrophic, distensible facial acne scars on the cheeks Works to treat acne scars by adding volume to skin, lifting and smoothing pitted acne scars leveling skin 01/07/15 FDA News and Events

3. New Drug Approval Savaysa™ (edoxaban) received FDA approval to reduce the risk of stroke and systemic embolism in patients with atrial fibrillation that is unrelated to a heart valve problem. Also indicated for treatment of DVT and PE in patients who have completed 5-10 days of therapy with a parenteral anticoagulant Black box warning stating to use alternative anticoagulant in patients whose creatinine clearance exceeds 95mL/min Oral factor Xa inhibitor 01/09/2015 FDA News and Events

4. New Drug Approval DUOPA™ (carbidopa/levodopa) received FDA approval for the treatment of motor fluctuations in people with advanced Parkinson disease Drug delivered via a small portable infusion pump Suspension goes through small intestines via procedurally-placed tube 01/13/2015 FDA News and Events

5. New Drug Approval Rytary™ (carbidopa/levodopa ER) received FDA approval for the treatment of Parkinson’s disease, post- encephalitic parkinsonism, and parkinsonism that may follow carbon monoxide intoxication or manganese intoxication Starting dose: 23.75/95mg TID, may increase to 36.25/145mg TID to QID Max dose 612.5 mg/2450mg 01/07/2015 FDA News and Events

6. Conversion of Immediate Release carbidopa/levodopa to Rytary

7. New Drug Approval Cosentyx™ (secukinumab) received FDA approval for the treatment moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy The most common side effects reported was nasopharyngitis 01/21/2015 FDA News and Events

8. New Drug Approval Prestalia® (perindopril/amlodipine) received FDA approval for treatment of hypertension: In patients not adequately controlled with monotherapy As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goals Doses include: (perindopril/amlodipine) 3.5/2.5mg, 7/5mg, and 14/10mg 01/21/2015 FDA News and Events

9. Generic Approval Nexium (esomeprazole) Approved for generic manufacturing: Esomeprazole 20mg Esomeprazole 40mg Approved to treat GERD in adults and children 1 year and older Continues to require prescription No release date available 01/26/2015 FDA News and Events

10. Update from Cone P & T 3 antibiotics were NOT recommended for the Cone Health formulary: Tedizolid (Sivextro) Oritavancin (Orbactiv) Dalbavancin (Dalvance)