1. Environmental Impact on Phenotype Section 8

2. Genotype, Environment & Phenotype The final physical appearance (phenotype) of an organism depends on the genetic information it carries (genotype) and the environment it is in This can be summed up in the following word equation: Genotype + EnvironmentPhenotype

3. Genotype & Phenotype Some characteristics that are solely based on genotype cannot be changed by the environment e.g. Having a widow’s peak Sunny climateRainy climate

4. Environment & Phenotype Other characteristics can be influenced by the environment they are in. E.g. If you are genetically predisposed to being tall, but you do not get enough food from your environment for growth, you may end up being smaller than your full potential

5. Twin Studies Identical twins are often used to determine the effects of genotype and environment on the physical appearance of an individual This is because identical or monozygotic twins have the same genotype

6. Factors That are and are not Inherited Genotypic traits are passed on to offspring because DNA is passed on from each parent to their child Environmental Factors ARE NOT passed on from one generation to the next because they usually do not help the species to evolve Environmental factors do not play any role in natural selection

7. Natural Selection An introduction

8. Charles Darwin “The Origin of Species”

9. Variation in characteristics All individuals in a species are different from each other. Some phenotypes are better suited to their environment. More likely that organisms with these phenotypes will survive to maturity and reproduce.

10. Environmental pressure Organisms produce more offspring than their environment can support. Predation, competition, overcrowding and disease resistance will limit the number of offspring surviving to maturity.

11. Inheritance Offspring often resemble their parents. Beneficial characteristics are passed on to offspring e.g. Ability to hide from predators

12. End Result Process is repeated generation after generation. Organisms with the more favourable phenotype are “selected” and survive. These organisms eventually become predominate in the population. SURVIVAL OF THE FITTEST

13. Variation in characteristics Environmental pressures. Only those with favourable characteristics survive. Inheritance. Favourable characteristics passed on to offspring. Organisms with most favourable characteristics predominant in environment.

14. Natural Selection Process by which only organisms best adapted their environment survive and transmit their genetic characteristics in increasing numbers to their offspring while those less well adapted tend to become eliminated.

15. Over to you Read “Environmental impact on phenotype” Do check test 8.1 Read “Natural selection” and do activity 6. Do check test 8.2

16. Peppered moth

17. 2 types

18. Pre industrial revolution Air clean Lichen light coloured. Light coloured moth less easily spotted by predators. More light coloured moths survived to pass genetic information to offspring. Light coloured moth prevailed.

20. Post industrial revolution Air not as clean. Lichen and tree trunks darkened with soot. Dark coloured moth better adapted to environment. Dark coloured moth breeds and passes genetic information to offspring. Dark coloured moth prevailed.

22. Summary Before Industrial revolution Air clean Lichen light coloured. Light coloured moth less easily spotted by predators - they are camouflaged. More dark coloured moths eaten by predators as easily seen. More light coloured moths survived to pass genetic information to offspring Light coloured moth more common. 1840 – Industrial revolution Air not as clean. Lichens die. Light coloured moth spotted by predators as trees darker Dark coloured moth better adapted to environment. Dark coloured moth survives, breeds and passes genetic information to offspring. Dark coloured moth more common.

23. Peppered moth game This link will allow you to be the bird eating the moths!This link will allow you to be the bird eating the moths!

24. Evolution The biodiversity of Earth is thought to have occurred through a very slow process known as evolution. Evolution takes millions of years and involves the process of natural selection.

25. Selective breeding An example of artificial selection

26. New varieties of plants have been produced through selective breeding by man. Most food plants bear little resemblance to their original wild variety. Original wild variety of corn is shown on the left of this picture, and modern corn on the right. This was achieved through many generations of selective breeding.

27. Selective breeding in cabbage plants Wild cabbage

28. Modern crop plants have been produced by selective breeding Wheat BarleyPotato Plants have been selected for: Increased disease resistance Higher yield (of seeds, potatoes etc) per plant

29. Ornamental plants Wild rose

30. Roses produced by selective breeding from the wild rose Plants are selected for: Scent Colour Stem length Shape Longevity

31. Wild ox ancestor Modern cattle Selective breeding in farm animals

32. Selective breeding has produced many varieties of cattle

33. Selective breeding in dogs

34. Collie Herding abilities Husky Ability to pull a sledge Thick coat Retriever ability to find and carry prey All of these varieties of dog have been produced by selective breeding over thousands of years from their wild ancestor, the wolf.

35. Inbreeding regression Inbreeding can sometimes cause problems! Shar pei

36. Bull dog –Have breathing difficulties –Difficult to give birth naturally to offspring

37. Golden Retriever Hip dysplasia Hereditary cataracts Other eye conditions

38. Selective Breeding Notes Selective breeding is the deliberate selection by humans of organisms which have some benefit to humans. Organisms with desirable characteristics are chosen to breed Undesirable organisms are not permitted to breed.

39. Characteristics which are often bred for include: –Increased milk yield in dairy cows. –Increased beef yield in cattle. –Increased disease resistance in crop plants. –Increased yield in crop plants. Advantages of selective breeding

40. Disadvantages of selective breeding Selective breeding takes a relatively long period of time. Results are not always guaranteed as there will always be some variation in the offspring.

41. Genetic Engineering

42. Insulin Production Insulin is a hormone made by the body to regulate the concentration of blood sugar. Diabetics are unable to produce this hormone. This can be treated by taking regular injections of insulin.

43. Insulin Production Insulin used to be extracted from pigs and cattle for human use because the hormone is similar, but not identical. Because the hormone is not exactly the same, it could sometimes cause allergic reactions. Producing insulin by genetic engineering overcomes this problem.

44. Insulin Production The gene for human insulin has been isolated and so the protein for insulin can be made by genetic engineering

45. Bacterial plasmids Plasmid cut open Part of human chromosome Gene for insulin cut out of chromosome Gene inserted into plasmid Plasmid inserted into bacterium Large circular chromosome

46. Notes! Using the previous diagram to help you, describe in words how human insulin can be produced by genetic engineering. List some advantages of genetically engineered insulin.

47. Applications of Genetic engineering Insulin Human Growth Hormone Factor VIII

48. Insulin Made by pancreas cells Diabetes: where insulin is not made or the body doesn’t react properly to insulin Insulin given to diabetics to relieve the symptoms of diabetes

49. Better Blood Haemophilia is a condition where a person is missing a vital protein to clot their blood. Genetic engineering can resolve this potentially fatal problem. Genetically engineering blood proteins is better than other treatments because there is less risk of infections.

50. Human Growth Factor Made by cells in the pituitary gland. Required for children’s growth and development. Given to children who cannot make enough of their own. Prevents reduced growth and dwarfism.

51. Applications of genetic engineering Product of genetic engineering Normal source and function Medical application of gene InsulinMade by pancreas cells; controls sugar levels in blood Given to diabetics who cannot make insulin Factor VIIIChemical In blood; require for blood clotting Given by injection to sufferers of Haemophilia who lack Factor VIII and whose blood fails to clot Human growth hormoneMade by cells in pituitary gland; Required for children’s growth and development. Given to children who cannot make enough of their own. Prevents reduced growth and dwarfism

52. Fighting Disease Antibodies are the body’s natural defence mechanism against foreign organisms such as bacteria and disease Antibodies give us immunity – the ability to protect ourselves from infection Oral vaccines are man made antibodies (proteins) that are absorbed into the body

53. Fighting Disease Simple bacterial cells cannot be used to make these oral vaccines because they are too simple Plant and animal cells are used because they can cope with making complex proteins

54. Fighting Disease Organisms which can produce medically important proteins AnimalsPlants CattleSoya Bean PigsMaize SheepSpinach GoatsTobacco Plant RabbitsRubber Plants Banana