1. Department of Biomedical Informatics Service Oriented Bioscience Cluster at OSC Umit V. Catalyurek Associate Professor Dept. of Biomedical Informatics Dept. of Electrical & Computer Engineering The Ohio State University

2. Department of Biomedical Informatics 2 Origins of caBIG Goal: Enable investigators and research teams nationwide to combine and leverage their findings and expertise in order to meet NCI 2015 Goal. Strategy: Create scalable, actively managed organization that will connect members of the NCI- supported cancer enterprise by building a biomedical informatics network “Relieve suffering and death due to cancer by the year 2015”

3. Department of Biomedical Informatics 3 Driving needs: cancer Biomedical Informatics Grid A multitude of “legacy” information systems, most of which cannot be readily shared between institutions An absence of tools to connect different databases An absence of common data formats A huge and growing volume of data must be collected, analyzed, and made accessible Few common vocabularies, making it difficult, if not impossible, to interlink diverse research and clinical results Difficulty in identifying and accessing available resources An absence of information infrastructure to share data within an institution, or among different institutions

4. Department of Biomedical Informatics What is caBIG? Common, widely distributed infrastructure that permits the cancer research community to focus on innovation Shared, harmonized set of terminology, data elements, and data models that facilitate information exchange Collection of interoperable applications developed to common standards Cancer research data available for mining and integration

5. Department of Biomedical Informatics 5 What is caGrid? A grid based software infrastructure consisting of services, toolkits, APIs, and applications A production grid deployment of the core services provided by that infrastructure A community of developers leveraging that grid and infrastructure to provide applications and services to the cancer research community

6. Department of Biomedical Informatics 6 What is caGrid? Development project of Architecture Workspace The Grid infrastructure for caBIG (the “G” in caBIG) Driven from use cases and needs of cancer research community Service Oriented Architecture Based on federation Model Driven Object-Oriented, Semantically-Annotated Data Virtualization

7. Department of Biomedical Informatics 7 What is caGrid? cont… Builds on existing Grid technologies Provides additional enterprise Grid components Grid Service Graphical Development Toolkit Metadata Infrastructure Advertisement and Discovery Semantic Services Data Service Infrastructure Analytical Service Infrastructure Identifiers Workflow Security Infrastructure Client tooling

8. Department of Biomedical Informatics 8 caGrid Community Involvement caGrid itself provides no real “data” or “analysis” to caBIG™; its the enabling infrastructure which allows the community to do so Community members add value to the grid as applications, services, and processes (for example: shared workflows) caGrid provides the necessary core services, APIs, and tooling The real “value” of the grid comes from bringing this information to the “end user” Community members develop end user applications which consume of the resources provided by the grid

9. Department of Biomedical Informatics 9 caGrid @ OSC Goals: Create an expandable caGrid Installation at OSC Deploy Pilot Applications to demonstrate Service Oriented Access to HPC resources Dorian, GTS and Index services are deployed cagrid-dorian01.osc.edu cagrid-gts01.osc.edu cagrid-index01.osc.edu SyncGTS along with Dorian and Index for performance caGrid 1.2 was released this week, and we deployed it!

10. Department of Biomedical Informatics Image Mining for Performing Comparative Analysis of Expression Patterns in Tissue Microarrays Project funded by NIH R01 (PI: David Foran, Co-PI: Joel Saltz) Development of innovative analysis methods for analysis of tissue microarrays Computation of features, annotations of image data based on features Development of software support to manage and share tissue microarray data and analysis results to process large volumes of tissue microarray data on high performance systems Development of ability to share data and analytical resources using caGrid Supports Help Defeat Cancer project which 100,000 imaged histology specimens originating from breast, head & neck, colorectal cancers. Pilot Application : TMA

11. Department of Biomedical Informatics 11 TMA Analytical Service Implementation TMA Application is a pipelined workflow Several processing steps that need to be applied in sequence to the images Build a prototype workflow orchestration system Wraps a program execution Stages the the data in Invoke the executable Retrieve the output files Uses caGrid’s bulk data transfer to move files from host to host Interacts with a scheduler to allocate resources for the execution Executable can be a parallel/distributed application TMA user interface Specify the workflow List with executables and parameters Invoke the service for the first stage

12. Department of Biomedical Informatics 12 What is next? Next Pilot Application: Prof. Dan Janies’ Supramap http://supramap.osu.edu Builds a phylogenetic tree and projects onto the map of the planet Computationally expensive Next Pilot Application(s): Your Application!? More Info: http://bmi.osu.edu and http://www.cagrid.orghttp://bmi.osu.eduhttp://www.cagrid.org Contact: Umit V. Catalyurek email: catalyurek.1@osu.edu