1. CHOICE Pathology Informatics 2010 Boston, Massachusetts DataReady ® : A Deployable Data Management and Integration System for Large-scale Cancer Repositories and Intelligent Databases © 2010 Integrated Solutions, Inc. All Rights Reserved

2. Jun-Min Liu’s Status report Tissue Micro Array (TMA) first introduced in 1998 Revolutionized the manner in which investigators address the challenges of limited tissue resources. Ideal TMA study: TMA blocks coupled with a data parameters images tissue diagnosis patient demographics other biomaterial descriptions quantified experimental results Technical Standards Committee of the Association for Pathology Informatics : XML based TMA data exchange specification Jun-Min Liu’s Status report Early Advances in Tissue Micro Array Data Exchange © 2010 Integrated Solutions, Inc. All Rights Reserved

3. Jun-Min Liu’s Status report Large-scale TMA projects continue to shift towards multi-institutional efforts Sharing information across centers and campuses Propel new advances in drug discovery and therapy planning Challenge: analysis and interpretation in large, decentralized, distributed environments Jun-Min Liu’s Status report A Shift Towards Multi-Institutional Efforts © 2010 Integrated Solutions, Inc. All Rights Reserved

4. Jun-Min Liu’s Status report Natural extension of the early efforts and advances made in TMA data exchange and integration: developed a prototype for automated TMA Integrated Solutions, Inc. (ISI) joined with The Cancer Institute of New Jersey (CINJ) at UMDNJ-Robert Wood Johnson Medical School to leverage early advances Concept system will feature both stand-alone and network modes for image analysis and mining for tissue microarrays Data sharing and integration system to facilitate the collection and management of bio-informatics data Jun-Min Liu’s Status report Advancements in Technology © 2010 Integrated Solutions, Inc. All Rights Reserved

5. Jun-Min Liu’s Status report Prototype Concept © 2010 Integrated Solutions, Inc. All Rights Reserved

6. Jun-Min Liu’s Status report Integrated Solutions, Inc. (ISI) is in a unique position to develop an application for the integration of the TMA Data Sharing Primary goals: User-friendly interface Quick and reliable selection of data resources for extraction and assessment Suite of tools that will enable investigators at strategically networked sites to quickly search, interrogate and integrate pathology metadata Data owner has full control of data sharing security Jun-Min Liu’s Status report Innovative Design Success in feasibility studies at The Cancer Institute of NJ Support from Emory University, University of Pennsylvania to Evaluate DataReady® TMA Data Center Sharing (TMADCS) © 2010 Integrated Solutions, Inc. All Rights Reserved

7. Jun-Min Liu’s Status report Concept Design © 2010 Integrated Solutions, Inc. All Rights Reserved

8. Jun-Min Liu’s Status report InfoSentinel ® Single Interface Technology (SIFT) Unique approach to the linkage of information Allows a single interface to communicate with multiple types of interfaces SIFT is compatible with industrial standards bridge the gaps between legacy and emergent technologies with minimum IT effort Jun-Min Liu’s Status report Innovative Core Technology © 2010 Integrated Solutions, Inc. All Rights Reserved

9. Jun-Min Liu’s Status report Data owner has full control of data sharing security Security Matrix offers: Full audit trail capabilities Track, manage, and record user account activity Maintain an itemized list of accessed data and resources Offers full capability to de-identify and re-identify data Jun-Min Liu’s Status report DataReady ® Security Matrix © 2010 Integrated Solutions, Inc. All Rights Reserved

10. Jun-Min Liu’s Status report DataReady ® Permission Matrix Interface © 2010 Integrated Solutions, Inc. All Rights Reserved

11. Jun-Min Liu’s Status report DataReady ® Study Management Interface © 2010 Integrated Solutions, Inc. All Rights Reserved

12. Jun-Min Liu’s Status report Expansion of archived reference images of pathology specimens and correlated clinical data Develop tools to support query-enabled databases distributed across multiple clinical and research sites Create a data analysis module that will serve as the integrated data analysis center Jun-Min Liu’s Status report Adaptability: Moving towards the Future © 2010 Integrated Solutions, Inc. All Rights Reserved

13. Jun-Min Liu’s Status report DataReady ® TMADCS Cancer Query System © 2010 Integrated Solutions, Inc. All Rights Reserved

14. Jun-Min Liu’s Status report Integrated Data Analysis Module © 2010 Integrated Solutions, Inc. All Rights Reserved

15. Jun-Min Liu’s Status report Pilot system for DataReady® TMADCS data integration management: illustrated efficiency and effectiveness in gathering information from multiple data sources provided by multiple sites Demonstrated results through successful complex queries related to tissue micro- array images, clinical subjects, and distributed environments Established success of our proposed data integration system in the use of pathology information and image management Extremely valuable tool to assist pathologists and clinicians in analyzing relevant TMA data effectively, efficiently and securely Inherent flexibility of the DataReady® TMADCS technology will assure continued success in data integration as the TMA data sharing grows and evolves Jun-Min Liu’s Status report DataReady ® TMADCS © 2010 Integrated Solutions, Inc. All Rights Reserved

16. Jun-Min Liu’s Status report Acknowledgements Center for Biomedical Imaging and Informatics at the Cancer Institute of New Jersey, UMDNJ- Robert Wood Johnson Medical School, Piscataway, NJ David J. Foran, PhD (djf@pleiad.umdnj.edu)djf@pleiad.umdnj.edu Wenjin Chen PhD Vicky Chu MS Integrated Solutions Inc., Holmdel, NJ. Rachel Wilhite MPH Esther Yu BS Jun-Min Liu PhD ASIFT Software, Holmdel, NJ © 2010 Integrated Solutions, Inc. All Rights Reserved