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This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity.

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Presentation on theme: "This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity."— Presentation transcript:

1 This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury. J Rehabil Res Dev. 2012;49(3):373–80. http://dx.doi.org/10.1682/JRRD.2011.04.0076 Slideshow Project DOI:10.1682/JRRD.2011.04.0076JSP Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury Ashraf S. Gorgey, MPT, PhD, FACSM; David R. Gater, MD, PhD

2 This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury. J Rehabil Res Dev. 2012;49(3):373–80. http://dx.doi.org/10.1682/JRRD.2011.04.0076 Slideshow Project DOI:10.1682/JRRD.2011.04.0076JSP Aim – Measure insulin-like growth factor-1 (IGF-1) in men with complete spinal cord injury (SCI) and spasticity. – Determine relationships between IGF-1 and thigh skeletal muscle cross-sectional areas (CSAs). Relevance – We hypothesized that spasticity could defend against muscle atrophy and deleterious changes in body composition through its effects on IGF-1.

3 This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury. J Rehabil Res Dev. 2012;49(3):373–80. http://dx.doi.org/10.1682/JRRD.2011.04.0076 Slideshow Project DOI:10.1682/JRRD.2011.04.0076JSP Methods 8 men with motor complete SCI underwent: – Magnetic resonance imaging to measure CSA of whole thigh, knee extensor, and knee flexor skeletal muscle groups. – Dual-emission X-ray absorptiometry to measure fat- free mass. We then measured their: – IGF-1 levels. – Spasticity (using Modified Ashworth Scale [MAS]).

4 This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury. J Rehabil Res Dev. 2012;49(3):373–80. http://dx.doi.org/10.1682/JRRD.2011.04.0076 Slideshow Project DOI:10.1682/JRRD.2011.04.0076JSP Results Plasma IGF-1 44% greater in those with MAS scores ≥2. Plasma IGF-1 positively related to knee extensor skeletal muscle CSA. IGF-1 strongly related to knee extensor and flexor spasticity. Relationship between IGF-1 and: (a)Knee extensor spasticity. (b)Knee extensor skeletal muscle CSA.

5 This article and any supplementary material should be cited as follows: Gorgey AS, Gater DR. Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury. J Rehabil Res Dev. 2012;49(3):373–80. http://dx.doi.org/10.1682/JRRD.2011.04.0076 Slideshow Project DOI:10.1682/JRRD.2011.04.0076JSP Conclusions Findings suggest that IGF-1 is greater in SCI individuals with increased spasticity. – May explain strong positive relationships noted between spasticity and skeletal muscle CSA. Maintaining muscle mass via spasticity or electrical stimulation resistance training may benefit body composition and insulin sensitivity and thereby improve health after SCI.

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