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Function Enrichment Score Enrichment p- value % genes in group that are present # genes in list, in group type I interferon-mediated signaling pathway48.19181.18E-2133.333321.

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Presentation on theme: "Function Enrichment Score Enrichment p- value % genes in group that are present # genes in list, in group type I interferon-mediated signaling pathway48.19181.18E-2133.333321."— Presentation transcript:

1 function Enrichment Score Enrichment p- value % genes in group that are present # genes in list, in group type I interferon-mediated signaling pathway48.19181.18E-2133.333321 cytokine-mediated signaling pathway44.70863.83E-2018.493227 response to virus27.7069.28E-1316.363618 immune response22.08872.55E-108.4805724 innate immune response18.07161.42E-088.715619 interferon-gamma-mediated signaling pathway18.03521.47E-0817.460311 double-stranded RNA binding14.75063.93E-0725.92597 chemotaxis13.17871.89E-0611 negative regulation of type I interferon production10.64092.39E-05255 defense response to virus10.59162.51E-0518.18186 inflammatory response10.00854.50E-056.8062813 ISG15-protein conjugation9.74555.86E-05603 phagocytosis, engulfment9.74555.86E-05603 blood circulation9.601896.76E-0515.38466 negative regulation of viral genome replication9.275469.37E-0528.57144 response to biotic stimulus9.065890.000115541503 positive regulation of interferon-alpha production9.065890.000115541503 nucleosome8.652790.00017463913.04356 IgG binding8.51980.0001994842.85713 cellular copper ion homeostasis8.063310.00031488337.53 superoxide-generating NADPH oxidase activity7.671350.0004659933.33333 cell-cell signaling7.650480.0004758185.687212 cellular response to heat7.023190.0008909827.27273 copper ion transport7.023190.0008909827.27273 nucleosome assembly7.011850.0009011449.677426 ISG15 ligase activity6.921110.00098673266.66672 regulation of defense response to virus6.921110.00098673266.66672 intracellular transport of viral proteins in host cell6.921110.00098673266.66672 cellular response to interferon-alpha6.921110.00098673266.66672 interleukin-1 beta secretion6.921110.00098673266.66672 detection of virus6.921110.00098673266.66672 RNA catabolic process6.500070.0015033423.07693 cytosol6.276490.001879992.8049643 modification-dependent protein catabolic process6.240070.00194972502 negative regulation of defense response to virus by host6.240070.00194972502 pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity6.240070.00194972502 tryptophan catabolic process to kynurenine6.240070.00194972502 protein kinase inhibitor activity6.062640.00232824203 microglial cell activation involved in immune response5.741330.0032105402 response to lipopolysaccharide5.480640.004166686.306317 negative regulation of erythrocyte differentiation5.347930.0047579733.33332 tryptophan catabolic process5.347930.0047579733.33332 hydrolase activity, acting on acid anhydrides5.347930.0047579733.33332 positive regulation of immune response5.023510.0065813728.57142 chemokine activity4.872440.007654649.302334 response to cold4.810690.0081422513.04353 positive regulation of tumor necrosis factor biosynthetic process4.747860.0086702252 JAK-STAT cascade4.690490.0091822312.53 protein dimerization activity4.598140.01007056.944445 defense response to bacterium4.560340.01045858.510644 Table S2. GO categories upregulated in early acute phase vs convalescent phase(P < 0.05) (HG-focus platform)

2 cyclin-dependent protein kinase inhibitor activity4.508560.011014322.22222 soluble fraction4.485210.01127453.7356313 activation of pro-apoptotic gene products4.362180.012750611.11113 positive regulation of interferon-beta production4.297420.0136036202 phosphatidylinositol binding4.262130.014092310.71433 complement activation, classical pathway4.262130.014092310.71433 signal transduction4.184040.01523692.8353326 response to unfolded protein4.166190.015511210.34483 interspecies interaction between organisms4.164370.01553954.0322610 regulatory region DNA binding4.108730.016428718.18182 immunoglobulin mediated immune response4.108730.016428718.18182 cell surface receptor linked signaling pathway3.941680.01941564.697997 cellular response to ionizing radiation3.938370.0194816.66672 positive regulation vascular endothelial growth factor production3.938370.0194816.66672 protein targeting to membrane3.938370.0194816.66672 acute-phase response3.818250.02196629.090913 extracellular region3.815140.02203462.6501830 gastrulation3.783260.022748515.38462 activation of caspase activity3.682420.02516216.557384 purinergic nucleotide receptor activity, G-protein coupled3.641030.026225214.28572 purine nucleotide biosynthetic process3.509840.029901713.33332 release of cytochrome c from mitochondria3.38820.033769512.52 negative regulation of phosphorylation3.38820.033769512.52 cysteine-type peptidase activity3.316630.03627497.53 regulation of immune response3.288650.03730435.79714 regulation of cyclin-dependent protein kinase activity3.192760.04105847.142863 cellular response to mechanical stimulus3.192760.04105847.142863 cysteine-type endopeptidase activity3.192760.04105847.142863 antigen binding3.168980.042046611.11112 aging3.141290.0432274.76195 cell communication3.133530.04356376.976743 chromosome3.081690.04588174.225356 response to organic substance3.075990.04614386.818183 signal transducer activity3.073330.04626662.9411815 induction of apoptosis by extracellular signals3.07180.04633765.405414 response to bacterium3.069590.046440410.52632 Table S2. continued

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