Presentation on theme: "Functions Receptors Signaling Chapter 11"— Presentation transcript:
1 Functions Receptors Signaling Chapter 11 CytokinesFunctionsReceptorsSignalingChapter 11Cut back on chemokine stuffDave gives a lot of that in the prior lectureFocus on signaling pathwaysAdd more on Th1/Th2
2 Cytokines are soluble mediators (small proteins) of innate and adaptive immunity and the mechanisms by which leukocytes communicate with one another.
3 Functions of cytokines stimulationinhibitiondifferentiationcell deathchemoattract
12 Cytokine receptors belong to families of receptor proteins, each with a distinctive structure (See also Abbas Figure 11-3A).
13 Cytokine receptors subfamilies have shared signaling subunits (see also Abbas Figure 11-3B).
14 Cytokine receptor function is regulated by expression of the subunits - the IL-2R story See also AbbasFigure 11-11
15 JAK-Janus kinaseSTAT-signal transducer and activator of transcriptionClass I and Class II cytokine receptors signal by a rapid pathway using receptor-associated kinases to activate specific transcription factors.Abbas Box 11-2
16 JAK/STATs Used by Key Cytokines See also AbbasBox 11-2 Table
17 Chemokines are a family of proteins of similar structure that bind to chemokine receptors, members of a large family of G protein-coupled receptors.CXCL8Rhodopsin bound to ligand retinal (structure predicted to be similar to chemokine receptor)