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Novel Mouse Model of Monocular Amaurosis Fugax by Dominique Claude Lelong, Ivan Bieche, Elodie Perez, Karine Bigot, Julia Leemput, Ingrid Laurendeau, Michel.

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Presentation on theme: "Novel Mouse Model of Monocular Amaurosis Fugax by Dominique Claude Lelong, Ivan Bieche, Elodie Perez, Karine Bigot, Julia Leemput, Ingrid Laurendeau, Michel."— Presentation transcript:

1 Novel Mouse Model of Monocular Amaurosis Fugax by Dominique Claude Lelong, Ivan Bieche, Elodie Perez, Karine Bigot, Julia Leemput, Ingrid Laurendeau, Michel Vidaud, Jean-Philippe Jais, Maurice Menasche, and Marc Abitbol Stroke Volume 38(12):3237-3244 December 1, 2007 Copyright © American Heart Association

2 Figure I. Branches of the internal carotid artery in relation to the ventral surface of the cranium in the rat (eye vascularization has not been determined accurately by other teams in the mouse).12. Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association

3 Figure 1. Fluorescence microscopy of flat-mounted, fluorescein-perfused retinas (group A). Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association

4 Figure 2. Fluorescence microscopy of flat-mounted, fluorescein-perfused right retinas at 2 reperfusion times (5 minutes and 1 hour) after acute ischemia for 15 minutes (group B15), 30 minutes (group B30), and 60 minutes (group B60). Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association

5 Figure 3. A, Summary of results (mean±SEM) showing the variation in a-wave amplitudes recorded under scotopic conditions with different flash intensities 4 weeks after 30 minutes of ischemia (n=11) or sham operation (n=11). Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association

6 Figure 4. A, Summary of results (mean±SEM) showing the variation in a-wave amplitudes recorded under photopic conditions with different flash intensities 4 weeks after 30 minutes of ischemia (n=11) or sham operation (n=11). Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association

7 Figure 5. Measurements of retinal layers thicknesses 4 weeks after 30 minutes of retinal ischemia or sham operation. Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association

8 Figure II. Comparison of sham-operated and ischemic mouse retinas stained with hematoxylin and eosin 4 weeks after 30-minute ischemia. Lelong D et al. Stroke 2007;38:3237-3244 Copyright © American Heart Association


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