1. Delivering clinical research to make patients, and the NHS, better Breast Cancer Research Report Site Specific Group Meeting Tuesday 13 th January 2015 Maxine Taylor Senior Research Delivery Manager

2. Content of report Overview of network changes Overview of research activity New studies for the portfolio Role research leads 2

3. Introduction NIHR Clinical Research Network merged all cancer research networks with all other clinical research networks in England on 1 st April 2014 CRN - West of England is one of 15 new networks This new geography does not map exactly to the site specific group geography. It now includes Gloucestershire and Swindon but no longer includes Taunton and Yeovil Taunton and Yeovil are served by the CRN – South West Peninsula I will work closely with my counterpart in South West Peninsula to support this SSG in full 3

4. West of England Population 2.4 million - Budget £13.2 million - 7 Acute Trusts - 2 Mental Health Trusts - CCL Principal Treatment Centre - Small core support team based at host in Bristol - Research will follow patient pathways regardless of network geography Map showing the 15 Clinical Research Networks in England

5. Purpose of the network Translation of national workstreams and objectives (generic and specialty specific) with strategic oversight of research activity within the geography of CRN - West of England in terms of: –Portfolio Balance, new studies, feasibility, industry trials –Performance Targets, support timely set up, support timely recruitment –People Skill mix, workforce flexibility, training, resources 5

6. Network Clinical Divisions Cancer Division 1 DiabetesRenal StrokeMetabolic & endocrine Cardiovascular Division 2 ChildrenReproductive health & childbirth GeneticsHaematology Division 3 Mental Health Dementias & neurodegenerative diseases Neurology Division 4 Primary careAgeingHealth services research Oral & dentalDermatology MusculoskeletalPublic Health Division 5 ENTAnaesthesia & pain management SurgeryCritical care RespiratoryOpthalmology Critical careInfectious diseases HepatologyGastroenterology Division 6

7. CRN - West of England Management Model Division s 2 & 6 Division s 3 & 4 Division 5 Division 1 Maxine Taylor Senior RDM Workforce Development Martine Cross Senior RDM RM&G and Industry Lead Ruth Allen RDM Business Intelligence lead Chantal Sunter RDM PCPIE and Comms Lead Mary Perkins Chief Operating Officer

8. The Clinical Team Dr Steve Falk Clinical Director 6 Divisional Clinical Leads Prof Hugh Barr for Div 1 30 Specialty Leads Sub Specialty Leads Sue Taylor Network Consultant Nurse Clinical Research Teams

9. NIHR CRN High Level Objectives Set up as fast as you can Recruit as many and as fast as you can All organisations involved Commercial and non commercial portfolio studies Cancer specialty specific objectives Recruitment overall at 20% of cancer incidence Recruitment to interventional studies at 7.5% of cancer incidence

10. How important is cancer on our patch? Cancer incidence 9544 242 recruiting studies £2 million (16%) Funding per incident case approx £220 Funding per recruit £800 Exceeded both recruitment targets for last 2 years Largest non commercial portfolio Benefit from continued good national and international links

11. West of England specialty portfolio compared to national Total studies 3827 WE total 546 =14%

14. Yeovil & Taunton recruitment by study design April – Nov 2014

15. Recruitment by Trust and study – April –Nov 2014

17. Cancer Subspecialty Research Leads Within each network 13 subspecialty research lead roles are identified, mapping onto the national Clinical Studies Groups with the aim of: –Providing link between local network and CSGs –Promoting the research agenda to clinical colleagues across the network and encouraging referrals –Advising on portfolio planning locally –Attendance at annual national meeting to discuss portfolio planning and delivery and horizon scan for new studies – first meeting 9 th March 2015 –Supporting the research delivery manager for the cancer specialty Role very similar to SSG Research Lead role 17

18. Imaging Adv. panel Screening, Prevention & Early Diagnosis CTRad (Radiotherapy) Psychosocial & Survivorship Teenage & Young Adult Teenage & Young Adult Palliative & Supportive Care Palliative & Supportive Care Biomarkers Adv. panel Primary Care Primary Care Consumer Liaison Group Breast Cancer CSG Breast Cancer CSG Lung Cancer CSG Lung Cancer CSG Upper GI Cancer CSG Upper GI Cancer CSG Colorectal Cancer CSG Colorectal Cancer CSG Kidney Cancer CSG Kidney Cancer CSG Bladder Cancer CSG Bladder Cancer CSG Testis Cancer CSG Testis Cancer CSG Gynae Cancer CSG Gynae Cancer CSG PPI Brain Tumours CSG Brain Tumours CSG Head & Neck CSG Head & Neck CSG Sarcoma CSG Sarcoma CSG Melanoma CSG Melanoma CSG Lymphoma CSG Lymphoma CSG Haematol. CSG Haematol. CSG Prostate Cancer CSG Prostate Cancer CSG Children’s Cancer & Leukaemia National Clinical Studies Groups

19. Division 1 Clinical Lead Brain cancer H&N cancer Lung cancer Breast cancer Sarcoma Skin Cancer Children/young people Upper GI cancer Colorectal cancer Urological cancer Gynae cancer Haem/lymphoma Pall/Supportive & Psychosocial 13 LCRN Subspecialty Leads: LCRN (x15) Clinical Director CRN WE Exec Board COO Division 1 RDM Research Delivery Teams Partnership Group Clin. Advisory Group [ +/- other clinical roles]

20. CRN – West of England Sub specialty lead for breast cancer research Surgery – Mr Zen Rayter Oncology – Dr Mark Beresford 20

21. Contact & reference details Maxine.taylor@nihr.ac.uk Hugh.barr@glos.nhs.uk http://csg.ncri.org.uk/portfolio-maps/ https://www.edge.nhs.uk/Account/Index?ReturnUrl=%2f http://www.crn.nihr.ac.uk/can-help/funders- academics/nihrcrn-portfolio/http://www.crn.nihr.ac.uk/can-help/funders- academics/nihrcrn-portfolio/ 21