1. NIAID Commitment to Influenza Research and Preparedness F. Gray Handley Associate Director for International Research Affairs National Institute of Allergy and Infectious Diseases National Institutes of Health January 28-31, 2007

13. U.S. Department of Health and Human Services

14. Administration for Children and Families (ACF) Food and Drug Administration (FDA) Health Resources and Services Administration (HRSA) The Secretary Deputy Secretary Administration on Aging (AoA) Centers for Medicare and Medicaid Services (CMS) Indian Health Services (IHS) Centers for Disease Control and Prevention (CDC) Substance Abuse and Mental Health Services Administration (SAMHSA) Program Support Center (PSC) Agency for Toxic Substances and Disease Registry (ATSDR) Agency for Health Care Policy and Research (AHCPR) National Institutes of Health (NIH)

15. Office of the Director National Institute o Alcohol Abuse and Alcoholism National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Dental and Craniofacial Research National Institute on Drug Abuse National Institute of Environmental Health Sciences National Institute on Aging National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Eye Institute National Human Genome Research Institute National Heart, Lung, and Blood Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of General Medical Sciences National Institute of Nursing Research National Library of Medicine Center for Information Technology Center for Scientific Review National Center for Complementary and Alternative Medicine National Institute of Allergy and Infectious Diseases National Center for Research Resources Clinical Center National Center on Minority Health and Health Disparities National Institute of Biomedical Imaging and Bioengineering Fogarty International Center National Institutes of Health

18. NIAID Basic Research on Influenza  Viral replication and evolution  Host-virus interactions  Mechanisms and sites that stimulate immune response  Immune correlates of protection related to seasonal influenza vaccination  Modeling the dynamics of influenza transmission in large human populations  Sequence analysis of the 1918 pandemic virus and its impact on human immune response

23. http://www.niaid.nih.gov/dmid/genomes/mscs/influenza.htm

24. NIAID Influenza Reagent Repository  Managed by BEI Resources  Makes reagents available to all registered researchers (including international) at no charge (shipping and handling fees only)  Influenza reagents currently available:  Purified H and N proteins  Poly and monoclonal antibodies  Influenza virus isolates  Peptide arrays designed for epitope mapping  Antiserum including human serum from H5 vaccinees Register at: www.beiresources.gov

29. H5 Influenza Plans Underway in SE Asia Increase training for investigators in SE Asia in areas related to clinical research and data management Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS. Develop research studies to examine cross- reactivity of H5N1 strains and molecular characterization of strains. Funding in FY06: $18 Million. Increase training for investigators in SE Asia in areas related to clinical research and data management Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS. Develop research studies to examine cross- reactivity of H5N1 strains and molecular characterization of strains. Funding in FY06: $18 Million.

58. Opportunities for Expanded Research Cooperation  Global networks focused on basic, translational, therapeutic, vaccine research  Viral characterization and ecology studies (human and animal)  Training in all areas  Seroprevalence studies  Cooperative sequencing of strains  Bioinformatics to facilitate access to sequence data and analysis tools globally and equitably

59. Key Funding Links  Collaborative projects involving investigators and institutions from international sites and the U.S. are particularly encouraged.  NIAID has a long-standing interest in and commitment to global health and international research.  Topics of interest for this program are limited to research on infectious diseases, including emerging infections that are of the greatest public health significance within the overseas country (e.g. tuberculosis; malaria; HIV/AIDS; sexually transmitted diseases; diarrheal, respiratory, and enteric diseases; viral hemorrhagic fevers; viral encephalitides; parasitic diseases; and vector-borne diseases).  Development of immunological, microbiological, biostatistical, epidemiological, and clinical research capacity is encouraged. Studies may be proposed on any aspect of infectious diseases (except clinical trials), including but not limited to: the epidemiology, pathogenesis, immunopathogenesis of infectious diseases; epidemiologic studies to define the incidence, clinical presentations, and outcomes of diseases; identification of resistance patterns; characterization of susceptible cohorts for a particular pathogen; pilot and feasibility studies in preparation for larger studies.  http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-06-041.html http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-06-041.html  http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html For further information contact Karen Lacourciere: lacourcierek@niaid.nih.gov