1. Regenerative Medicine Society 13/05/2015 Preventative Medicine, Biotech & Bioinformatics Combat Degenerative Diseases

2. Introduction What is the aim of the group  Advocate Regenerative/Preventative Bio-medical Therapies from Ireland  Encourage Research and Development in Preventative Medicine and Cures to Combatting Age related and other degenerative diseases  Public Education/Awareness of advancements in these areas of medicine/technology

3. Introduction Who we are:  Brian Collins - Former Biotech Engineer/Analyst Founder of Regenerative Medicine Society Founder of Preventative Med & Biotechnology Group  Barbara Cottier – Assistant & Administrator

4. Introduction  Recent Developments  Google Calico (September 2013)  Longevity Inc (February 2014)  In Silico Medicine (March 2014)  Large Scale Corporate Development

5. Main Affiliations  SENS (Strategies for Engineered Senescence)

6. Known Aging Mechanisms – SENS Aging Model Please note this list is not necessarily exhaustive

7. SENS Affiliations  Some Leading Universities collaborating with SENS:  Harvard - George Church – Gene Therapy and Cancer  MIT-Robert Langer-Biomaterials, Stem Cells  YALE - David Spiegel –Cardiovascular/Skin/Muscular Aging  RICE University - Pedro Alvarez - Cellular Damage  Cambridge-Mark Kotter- Stem Cell and Gene Delivery  Moscow State University-Vladimir Sculachev – Mitocondrial Therapy  Marie Curie University Paris - Marisol Corral-Debrinski - Mitocondria  University of Tobingen - Graham Pawelec - Immunotherapy

8. Interested Therapies & Technologies  Stem Cell Therapy and Organ/Tissue Growth  Gene Therapy  Immunotherapy and Immunosuppressants  Biomaterials  Molecular Enzyme and Hormone Therapy  Proteomoic/Protein Expressions  Nanotechnology  Electronic Medical Diagnostics-Preventative diagnostics  Bio Informatic  General Preventative Medicine

9. Topic This Evening: Epigenetics & Epigenetic Therapeutics Science/Technologies: (epi)Genetics & interactions Gene & RNA Sequencing RNA interfacing Micro RNA Neurogenomics Epidrugs & Epitherapeutics

10. Recent Breakthroughs  Role of Epigenetics on health, psychology, aging, gender & memory/intelligence  Epigenetic cross generation influence  Epigenetic interfacing, use of transcription factors & micro RNAs  Development of RNA sequencing and epigenome  Application of epidrugs & epigenetic therapeutics for cancer

11. Videos for the Evening  Introduction to Epigenetics: https://www.youtube.com/watch?v=i9a-ru2ES6Y Epigenetics Overview:  https://www.youtube.com/watch?v=JTBg6hqeuTg Sens Confereence, Epigenetics & Agings https://www.youtube.com/watch?v=ktxCNQ_mNv0 Aging, Epigenetics & Blood Swap https://www.youtube.com/watch?v=kRp-e4y6yoY Epigenetics Cross generation Influence: https://www.youtube.com/watch?v=NecRvk6dG7k Epigenetic Therapies for Cancer: https://www.youtube.com/watch?v=xQH6mcmBRqk

12. Recommended Resources http://www.sens.org/ More Information about SENS, Aging & Biology : Brain Gender: http://www.sciencealert.com/brain-gender-is-more-fluid- than-originally-thought-research-reveals Reverese aging by altering genetic expression: http://www.psychiatrictimes.com/geriatric- psychiatry/blood-revival-young-mice-reverse-aging-old Epigenetics & Depression: http://www.whatisepigenetics.com/the-epigenetics-of- depression/ Epigenetics & Neural Plasticity/Memory: http://www.ncbi.nlm.nih.gov/pubmed/24484706

13. Support Research in Ireland  Fundraise relevant research in Ireland  Provide platform for collaboration with our international colleagues

14. Raise Public Awareness  Educational Initiatives  Press Relations  Documentaries  National Education Petitions  Webcasts  Regular Guest Speakers  Possible Publishing of New Book about development in this area of Medicine (for Lay readers)

15. PM/Regenerative Med Society Platform  Meetups monthly (Parallel: Activity and Social Meetups)  Social Media and Websites for information and activities to support this cause  People required with Science (Biology, Medicine, Informatics/Programming, Engineering, Physics),  Advertising/Event Promotion and people from all backgrounds actively welcomed

16. What to Do Now  Sign up on Facebook, Meetup, and website (when functional)  Invite ten others to join on Facebook  Read up on relevant developments on Facebook and Website  Invite interested friends to next Meetup  Help distribute future email/facebook petitions

17. Q & A

18. Suggestions

19. Why are we doing this? FUN! NOT FUN!