1. Cellular Basis of Learning and Memory
BIPN 148
Spring 2006
April 3-June 9, 2006
This course will examine the cellular and molecular mechanisms that underlie learning and memory. Topics covered will include the role of the hippocampus in learning and memory, neurotransmitter systems and receptors involved in learning and memory, and biochemical mechanisms of synaptic plasticity. Emphasis will be placed on discussing experiments from the primary literature. A solid background in cell and molecular biology is expected.
Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended.
Times: MWF at 4:00
Location: CSB 001
Web Site:
Recommended Text Ghosh and Scanziani Lecture Notes
Lecture notes are available for purchase through University Readers at
Grading: Weekly Quizzes: 30%
Group paper and presentation: 30%
Final Exam: 40%
Grading is on a curve.
Discussion Sessions/TA office hours (optional): Pacific Hall 1115
Wednesdays at 5:00
Fridays at 3:00
Contact Information
Professors: Anirvan Ghosh, Pacific Hall 1123,
Massimo Scanziani, CMG 2nd Floor,
TEACHING ASSISTANTS: Will Barkis and Mark Chen

2. Subdivisions of Human Memory
DECLARATIVE
(EXPLICIT)
NONDECLARATIVE
(IMPLICIT)
FACTS
EVENTS
PROCEDURAL
(SKILLS AND
HABITS)
PRIMING
SIMPLE
CLASSICAL
CONDITIONING
NONASSOCIATIVE
LEARNING
EMOTIONAL
RESPONSES
SKELETAL
MUSCULATURE
MEDIAL
TEMPORAL
LOBE
STRIATUM
NEOCORTEX
AMYGDALA
CEREBELLUM
REFLEX
PATHWAYS
Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:

3. Classical Conditioning (an example of implicit memory)
Ivan Pavlov

4. Implicit Memory: Pavlovian Associative Conditioning
Conditioned
Stimulus
Unconditioned
Response

5. Implicit Memory: Fear Conditioning
TRAINING
CONTEXTUAL TEST
CUED TEST
Animal is placed in novel context
Hears a tone
Receives foot shock
Animal is returned to same context
Test for freezing behavior
Animal is placed in modified context

6. Implicit memory: Conditioned Taste Aversion
DAY 1 B
1.0
1st Exposure to Food Item
0.8
0.6
grams blueberry bar
0.4
Injection of LiCl or NaCl
0.2
DAY 2
0.0
LiCl
NaCl
Grams Ingested on 2nd Exposure
(LiCl treated group compared to NaCl treated control)
2nd Exposure to Food Item

7. Implicit Memory: Neophobia
DAY 1
1st Exposure to Food Item
0.0
0.2
0.4
0.6
0.8
1st intake
2nd intake
grams blueberry bar
DAY 2
2nd Exposure to Food Item
Grams Ingested
(1st exposure compared to second exposure)

8. (Distinction between short-term
Hermann Ebbinghaus
(Distinction between short-term
and long term memory)

9. Ebbinghaus Test ZOG MIF XEL RIC DAJ NEQ SOR YAN QIJ GEB
Memorize this set of words
ZOG
MIF
XEL
RIC
DAJ
NEQ
SOR
YAN
QIJ
GEB

10. (keep the words in mind!)
Wait for 1 minute
(keep the words in mind!)

11. Write down the words in sequence Did anyone get all 10 right?

12. By testing subjects after various delays Ebbinghaus developed
the concept of short-term and long term memory
Sensory Information
Working Memory/Short term Memory
(Minutes)
Long Term Memory
(Hours/Days/Years)

13. Working Memory Requires Frontal Lobe Function
neuro3e-fig jpg

14. Declarative Memory Required the Hippocampus
neuro3e-fig jpg

15. neuro3e-fig jpg