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1 Chapter 28 Growth, Development and Differentiation Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
2 FIGURE 28-1: The neural tube forms enlarged vesicles that correspond to major brain regions. (A) The neural tube as it appears on the dorsal surface. First three and then five major brain vesicles (B) form that give rise to the entire brain. Arrows correspond to (C) sagittal section and (D) cross-section, which reveal major brain regions. (E) Adult spinal cord cross-section reflects simple dorsal alar sensory and ventral basal motor neuron pattern established in the embryo. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
3 FIGURE 28-2: Dorsoventral patterning of the neural tube. (A) The neural tube is exposed to bone morphogenetic proteins (BMPS) from the dorsal epidermis and sonic hedgehog (shh) from ventral notochord. These set up secondary signaling centers in the roofplate and floorplate, respectively. (B) Implantation of a second notochord adjacent to the intermediate neural tube induces a second floorplate and additional adjacent motor neurons. (C) The two signaling centers establish a gradient of signaling that results in (D) differential transcription factor expression, depending on position in the neural tube. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
4 FIGURE 28-3: Homeotic genes regulate rostrocaudal patterns conserved in fly and mammal. (A) The fly embryo is patterned in sequentially smaller domains by maternally derived polarity, gap, pair-rule, segment polarity and homeotic genes. (B) Homeotic genes are conserved in fly Hom-C cluster and mammalian 4 Hox gene clusters. Mouse genes with higher numbers are expressed later and more posteriorly. Retinoic acid levels are high in posterior regions. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
5 FIGURE 28-4: Cell division in the neural tube gives rise to cortical neuron layers. Symmetric cell division early gives rise to similar cells, while asymmetric cell division gives rise to a precursor and a neuron. Postmitotic neurons migrate on radial glial cells to form layers of distinct cortical neurons. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
6 FIGURE 28-5: Embryonic signaling centers in the brain. A rostral patterning center at the septum secretes fgfs; a dorsal center called the cortical hem secretes wnts and bmps, and a mid/hindbrain isthmus secretes fgfs. From Hoch et al., (2009). Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
7 FIGURE 28-6: Development of the spinal cord. The neural tube rounds up with dorsal (alar) regions and ventral (basal) regions, separated by the sulcus limitans. This early neural tube structure is largely unchanged morphologically in the adult spinal cord, with layers of ventricular (ependymal), mantle (neuron cell bodies)- and marginal (axonal) layers. In the telencephalon, some precursors migrate tangentially from the ganglionic eminences and also give rise to cortical neurons. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
8 UNN FIGURE 28-1
9 FIGURE 28-7: Neural crest cell progeny are affected by tissue signals. The neural crest gives rise to sensory dorsal root ganglion neurons and glia, peripheral nerve Schwann cells, and autonomic sympathetic and parasympathetic neurons, among other derivatives. The dorsal aorta expresses BMPs early in development that are important for adrenergic differentiation (left). If a bead with a BMP inhibitor is implanted, adrenergic neurons do not form in sympathetic ganglia (right). If BMP is overexpressed, many more neurons are adrenergic. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
10 FIGURE 28-8: Synapse formation at the neuromuscular junction. Motor neurons secrete agrin at contact points with the myofiber and can cluster agrin receptors and MuSK, which in turn can cluster AChRs via the action of rapsyn at those sites. Copyright © 2012, American Society for Neurochemistry. Published by Elsevier Inc. All rights reserved.
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