1. The Research and Development Ecosystem R.V. Duncan, Ph.D. Vice Chancellor for Research Rotary Presentation October 12, 2011

2. Restore the Frontier! According to the NY Times on 9/29/10: The Midwest will has declined to 94 Congressional seats following the 2010 U.S. Census, down from an all-time high of 143. Major Midwest Universities like MU can help reverse this trend

3. MU = 1/3 Health + 2/3 University Last year, University of Missouri Health Care admitted 20,260 patients, performed 19,222 surgeries, recorded 510,897 clinic visits and 42,995 emergency-center visits. MU is one of only six public universities in the country with medicine, veterinary medicine, public health, law, engineering and agriculture all on one campus.medicineveterinary medicinelawengineeringagriculture MU makes major investments in inter- disciplinary research centers, such as the BLSC, MURR, Dalton, RBL, I 2 NM 2, and others. $55M/year out of $240M+ MU’s total budget is just under $2B

4. Unprecedented Research Growth MU attracts over 70 percent of the federal research dollars flowing to Missouri's public universities. In 2010 MU spent over $44M of NSF funding, the most in Missouri, out of $119M total in State. In 2010 Thompson Reuters ranked MU 8 th in the USA and 15 th in the world for plant and animal sciences research impact. Total External Academic Contract and Grant Awards in 2010 totaled $485M, up $210M over 2006 level.

5. 2011 Fall Enrollment Record enrollment of 33,800+ Students represent every Missouri county, every state and 100+ countries Very strong student body growth, averaging over 3% per year while many other university growth rates are flat or declining. ACT scores are highest in a decade! All out-of-state growth with improvement in student body diversity

6. What Are We Adapting to? A VERY rapidly increasing student body! Mizzou Advantage has catalyzed new teams, and conveyed MU’s strengths concisely to the public. Emergence of on-line education, with national emphasis on workforce preparation over R&D Rapid expansion of industrial interest in MU’s R&D capabilities. Rapidly growing student interest in free-market pursuits, and rapidly declining State support…

7. Change in Core Funding Sources 70% 27% 3% 39% 54% 7% Core budget for on-campus teaching and support services

8. 2001-10 State Support Falls Short of Inflation $245M $319M $193M $189M 0 25 50 75 100 125 150 175 200 225 250 275 300 325 350 2001200220032004200520062007200820092010 millions 2010 shortfall: $130M Shortfall since 2001: $728M Inflation Adjusted Inflation & Enrollment Adjusted Actual Received

9. Technology Commercialization Rapid growth in Intellectual Property Licensing Revenues, Disclosures, and Licensing Deals. Licensing revenues total almost $60M from over $1B in gross sales by companies that licensed MU technology Licensing revenues grew from $4.7M in FY07 to $10.1M in FY09, representing a 600% ROI in 2009. A small decline since then in gross revenues, as net revenues increased. Missouri Life Sciences Business Incubator at MU Dedicated in May, 2009 Jake Halliday, Executive Director Coulter Opportunity!

10. Technology Transfer Challenges The Interface at which we operate UNIVERSITYINDUSTRY Commercialization of New and Useful Technologies Teaching Research Service Economic Development Profits Product R&D Knowledge for Knowledge’s Sake Academic Freedom Open Discourse Management of Knowledge for Profit Confidentiality Limited Public Disclosure

11. Technology Commercialization, Con’t. Savage River Farms venture capitalized by Kleiner Perkins, and delivering product as of 9/2/11. MU has licensed the IP, taken equity in the company, and secured a commitment for a Missouri plant within five years. Shasun NBI, LLC attracts millions of dollars from Chennai, India to create high-end drug development jobs in Missouri Organovo was named as one of the top 50 inventions of 2010 by Time Magazine, and is now going public. Proposed system for making 150M gallons / year of butanol from woody biomass along major river valleys in the USA At last years R&D Advisory Board Meeting, VC Martin Sanders teamed with MU Professor John Viator to create a company that detects blood- borne pathogens photo-acoustically.

12. Organovo and Organ Printing Invented by Professor Gabor Forgacs at MU See: http://www.organovo.com/ C.E.O.: Keith Murphy The Economist Magazine

13. Pharmaceutical Research MURR Center College of Veterinary Medicine School of Medicine Chemistry and Biochemistry Physics and Radiology

14. MURR Pharmaceutical Research 25-year history of successful and innovative pharmaceutical research, including the development of: Ceretec TM (with 99m Tc), a diagnostic used to evaluate cerebral blood flow in patients. Quadramet ® (with 153 Sm), a therapeutic for treatment of pain associated with metastatic bone cancer. TheraSphere ® (with 90 Y), a glass microsphere used to treat patients with inoperable liver cancer. Zegerid ®, an antacid and not a radio-pharmaceutical, is by far our most successful drug ever, with over 40 million dollars in royalties and over a billion dollars in total sales.

15. Impact: Plant and Animal Sciences Institution Papers CitationsCitations/paper 1John Innes Centre, UK 1,134 42,568 37.54 2RIKEN, Japan 926 25,453 27.49 3Max Planck Society, Germany 2,858 65,851 23.04 4University of California, San Diego 1,143 25,349 22.18 5University of California, Berkeley 2,12143,417 20.47 6University of Arizona 1,717 31,073 18.10 7CNRS, France 2,303 33,022 14.34 8University of Washington 2,226 31,089 13.97 9Wageningen University 4,083 54,517 13.35 10University of Cambridge 1,949 25,875 13.28 11CSIRO, Australia 3,729 49,339 13.23 12Cornell University 4,912 64,964 13.23 13Washington State University 2,47332,544 13.16 14University of Wisconsin 3,977 52,336 13.16 15University of Missouri 2,497 30,756 12.32 16Purdue University2,673 32,600 12.20 17INRA, France 6,199 75,164 12.13 18Michigan State University 3,469 42,055 12.12 19University of British Columbia 2,539 29,670 11.69 20Iowa State University 2,682 31,115 11.60

16. Thought for the Day If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance. Orville Wright