1. Vascular Disorders Monique Killins Roll # 1043 Windsor University School of Medicine

2. Introduction Vascular Disorders occur because of inflamed blood vessels ​ Inflammation: neutrophils, macrophages and lymphocytes

3. Symptoms Fever ​ Fatigue ​ ​ Night sweats ​ Muscle and joint pain ​ Loss of appetite ​ Weight loss ​​

4. Signs ​ Blood Test: ​ high WBCs, high platelets, low red blood cells, high ESR ​ Urine Test : ​ red blood cells, protein (assess kidney function) ​ Biopsy displaying signs of inflammation ​

5. Causes ​ Idiopathic ​ Infection: Hepatitis B, C ​ Drugs: birth control pills, erythromycin ​ ​ Toxins ​​

6. Churg-Strauss Syndrome Asthma ​ Allergic problems ​ Chronic nasal inflammation ​ Inflammation damaging skin, nerves, lungs and kidney ​ SYMPTOMS ​ COUGH ​ FACIAL PAIN ​ RASHES ​ SHORTNESS OF BREATH ​

7. Giant Cell Arteritis large and medium blood vessels ​ head, neck, upper body and eye vessels affected ​ SYMPTOMS ​ SCALP PAIN ​ JAW PAIN ​ BLURRED VISION

8. Wegener Granulomatosis small and medium sized blood vessels ​ inflammation of upper airway, lungs and kidney ​ SYMPTOMS ​ CHRONIC SINUSITIS ​ NOSEBLEEDS ​ CHEST PAIN ​ COUGH ​

9. Management Treat primary problem ​ Corticosteroids:prednisone ​ Immunosuppressants :cyclophosphamide, rituximab, methotrexate ​

10. Complications Hemorrhage ​ Kidney Failure ​ Treatment Complications: ​ decreased bone density, high blood pressure, cataracts, weight gain, diabetes; immunosuppressant related infection

11. Case Study A 26-years-old man was referred with decreased visual acuity for one week in the left eye. Headache was a accompanying complaint and he was overwhelmed by oral ulcers. On ophthalmologic examination, he had a visual acuity of 16/20 on both eyes. Color vision tested with Ishihara plates was 12/12. The anterior segment was normal and intraocular pressure measured with applanation tonometer revealed 12 mmHg on the right eye and 11 mmHg on the left eye.

12. References http://www.merckmanuals.com/home/bone _joint_and_muscle_disorders/vasculitic_di sorders/overview_of_vasculitis.html ​ http://www.casesjournal.com/content/2/1/7 528 ​ http://courses.washington.edu/conj/inflam mation/chronicinflam.htm ​ http://www.nlm.nih.gov/medlineplus/ency/a rticle/000226.htm ​ ​ Windsor University Pathology I Lecture ​ Google Images ​