1. Speckle Noise Reduction in Optical Coherence Tomography By: Marisse Foronda Rishi Matani Hardik Mehta Arthur Ortega

2. Cow Retina

3. Speckle wave fronts sample volume multiple forward scatter multiple back scatter tissue modulated wave fronts

4. Background Minimally-Invasive to Non-Invasive imaging system Clinically used High Resolution alternate to ultrasound imaging One significant problem is speckle formation

5. Deformable Mirror

6. Intensity Loss Varying Patterns can cause loss of intensity of image and change in percent reflectivity First, we must characterize default intensity loss by placing a flat mirror at the sample arm and having no deformations on the deformable mirror Then, we deform mirror and characterize loss: 3 dB loss  50% loss 6 dB loss  75% loss 9 dB loss  87.5% loss

7. Image Assembly 100% 80% Amplitude % light reflected Pattern 1 Pattern 2 Amplitude % light reflected 100% 80%

8. Contrast Ratio

9. Correlation If two images have speckle patterns that are the same, averaging them gives us no reduction in that speckle We have to characterize how similar two images are using the formula:

10. Gantt Chart

11. Weekly Progress Week 1 Read Papers on our Design Familiarized ourselves with the lab Week 2 Took Measurements of Components Drew out a system diagram Week 3 Ordered all necessary components Began assembling the system Week 4 Fine tune/align the system Defective Galvo cables diagnosed Week 5 Waiting for new Galvo cables Week 6 Finish Assembly of Device Week 7 Finish Assembly of Device Week 8 Galvo Wires arrived Week 9 Fine Tuning/Alignment

12. Prototype System

13. Reverse Alignment

14. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 0 µW 2.5 mW 526  W 480  W

15. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 1 µW 2.5 mW 526  W 480  W

16. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 5 µW 2.5 mW 526  W 480  W

17. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 10 µW 2.5 mW 526  W 480  W

18. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 20 µW 2.5 mW 526  W 480  W

19. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 35 µW 2.5 mW 526  W 480  W

20. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 50 µW 2.5 mW 526  W 480  W

21. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 80 µW 2.5 mW 526  W 480  W

22. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 125 µW 2.5 mW 526  W 480  W C2 M C1 input output G

23. Forward Alignment

24. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 10 µW 2.2 mW 2.1 mW 486  W

25. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 30 µW 2.2 mW 2.1 mW 486  W

26. deformable mirror fiber and collimator 2D-galvo scanners fiber and collimator 3.0 mW 119 µW 2.2 mW 2.1 mW 486  W C1 MG C2 Input Output

27. Power Results Forward Alignment PathPower% Loss Input-C13.0 mW C1-M2.2 mW26.7% M-G2.1 mW4.5% G-C2486 µW76.9% C2-Output119 µW75.5% Reverse Alignment PathPower% Loss Input-C13.0 mW C1-M2.5 mW16.7% M-G526 µW78.9% G-C2480 µW8.7% C2-Output125 µW74% -AR (anti-reflection) coating on Galvo mirrors (1310 nm) -Fibers (1310 nm) -Power Source (800 nm)

28. Conclusion Quantitative Benchmark: Reduce contrast ratio by 25% - 50% with a 6 dB mean intensity loss Future Applications: Any Imaging system using a coherent light source can easily integrate the deformable mirror component. Integration of the mirror will be efficient and cost effective.

29. Questions