1. 3-04-11 IN How would you define a genetic disorder? Write a list of genetic disorders.

2. 3-04-11 Quiz Notes on genetics OUT NONE

3. Case studies of two Genetic Disorders Open your book to page 496 Read essay

4. Phenotype and Genotype Notes: Notes: Phenotype---observable traits of an organism. Blood type, eye color, petal color Genotype decides phenotype Environmental factors can influence how genetic information produces a phenotype. Height (based on nutrition and genotype)

5. Genotype--the genetic plan that is found in cells of organisms. Stored in DNA(deoxyribonucleic acid) molecules Found inside cell, nucleus Packed inside the nucleus are chromosomes(Humans=46;23mom+23 dad) DNA molecules organized around proteins Gene-a small piece of genetic information

6. Allele-one of two or more possible forms of a gene.Each affects the hereditary trait somewhat differently. S=straight earss=floppy ears Organisms that reproduce sexually receive one allele from each parent Heterozygous-have two different alleles Ss

7. Homozygous-having two of the same alleles SS or ss Dominant trait- presents itself whether the organism is homozygous dominant (SS) or heterozygous (Ss) SS=Straight earsSs=Straight ears Recessive trait- presents itself only when the organism is homozygous recessive (ss) ss=Floppy ears

8. Independent assortment --traits are independent of each other. More combinations are possible Opposite to sex-linked Genes for traits are on different chromosomes

9. 5. In cocker spaniels, black B is dominant over red b. Solid color S is dominant over white spotting s. A red male was mated to a black-and- white female. They had five puppies, as follows: one black, one red, one black and white, and two red-and-white. A. What genetic principle explains the phenotypes of these offspring? B. Write a one or two paragraphs to describe how that principle worked in this cocker spaniel family. Include the following terms; gene, phenotype, dominant trait, recessive trait, chromosome, allele, genotype

10. Case studies of two genetic disoders Huntington’s disease- a dominant genetic disorder that causes degeneration of the central nervous system. Symptoms occur after 35 NO cure Disease causes the brain and nerves to slowly shutdown for up to 15 years, then person dies Genotype Hh or HH

11. Cystic fibrosis -- a recessive genetic disorder that affects the respiratory system. Symptoms show at birth Lungs are clogged with thick mucus Affects digestive system as well because of mucus Possibilities range between races Genotype cc NO cure, person usually dies at a young age However, antibiotics, vapor therapy, and chest thumping help

12. Other genetic disorders to research: Down syndrome Sickle-cell

13. Would you test to see if you and your partner carry genetic disorders? What are the advantages of knowing you have alleles for genetic disorders? What are the disadvantages of knowing you have alleles for genetic disorders?