1. Centre for NanoHealth Swansea University www.nanohealth.swansea.ac.uk Centre for NanoHealth Future Healthcare Dr Steve Conlan Director - Centre for NanoHealth Institute of Life Science School of Medicine

2. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Overview Nanotechnology NanoHealth Impact of NanoHealth Centre for NanoHealth Challenges and Opportunities R&D

3. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Please turn off your Nanotechnology based devices.

4. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University The nano-scale

5. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University What is NanoHealth?

6. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Ability to manipulate and control the properties and interaction of material where at least 1-D is nm. Structural Mechanical Electronic Optical Chemical Biological Computational Modelling Nanotechnology… Multidisciplinary …For Healthcare

7. Centre for NanoHealth Swansea University www.nanohealth.swansea.ac.uk The impact of NanoHealth

8. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University NanoHealth… … has the potential to impact on the prevention, early and reliable diagnosis and treatment of diseases. European Technology Platform on NanoMedicine Vision Paper (2005) NanoHealth embraces five main sub-disciplines that in many ways are overlapping Analytical Tools Imaging Tools Materials and Devices Novel Therapeutics and Drug Delivery Systems: ‘Nanomedicines’ Clinical, Regulatory and Toxicological Issues ESF forward look on Nanomedicine (2005)

9. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Diagnosing and treating diseases Enhancing early intervention Non-hospital environments Personalised Medicine Impact on Healthcare

10. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Economic Impact

11. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Economic Impact

12. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Global Networks/Global Investment EU, US, South America and Asia Alliance for Nanohealth ETP for Nanomedicine

13. Centre for NanoHealth Swansea University www.nanohealth.swansea.ac.uk Centre for NanoHealth

14. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Partnership for Success Institute of Life Science £52m collaborative venture between IBM, Swansea University, WAG, opening its doors in 2007 Home in the Medical School, 25 specialist teams (27 Professors and 220 Research active staff) Multidisciplinary Nanotechnology Centre More than £5M funding in 2002 from HEFCW, Royal Society/ Wolfson Foundation, SRIF and Swansea University Home in Engineering, major research centre (20 academic staff, 20 RAs and 40 PhD students) Outstanding RAE 2008 results (THES) MNC 5 th out of 52 in UK in General Engineering, 80% of activity rated 4* and 3* ILS 7 th out of 70 in UK in Allied and Professional Health, 55% of activity 4* and 3*

15. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Partnership for Success Successfully managed Objective 1 project On time - On budget Outputs met– sustainability/job creation/strong links with business/IP Blue C IBM partnership Interdisciplinary research base University NHS Trust Patient base of 600,000+ Partnership with ILS and MNC Joint MNC and ILS laboratories in Morriston Hospital Commitment to CNH Successfully managed HEFCW project Model interdisciplinary centre Self-sustaining (£2M per year) Strong links with business/IP Pan-Wales focus for nanotech

16. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Centre for NanoHealth £22M EU Convergence funded project, started January 2009 12 new staff (8 academic, 4 project management and delivery). £13M investment in state of the art open access nano- and bio-facilities. Industry to come and work with us, access to facilities, expertise and incubation space. Unique interdisciplinary R&D environment Based on the application of Nanotechnology Leading innovations in Healthcare. Driving the Knowledge Economy

17. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Centre for NanoHealth

18. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Project Funding £22 Million, 5 year Knowledge Economy project Supported by: WEFO [£10.5 Million] DHSS [£1.5 Million] Swansea University [£7.6 Million] Industry [£2.5 Million]

19. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University CNH Targets & Deliverables Establishing a European R&D Centre of Excellence Assisting 400 Enterprises (>80% Welsh SMEs) Assisting 100 Individuals Creating 450 Jobs Achieving sustainability by 2014 Through Welsh, UK, Industrial and EU funding

20. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Building opens Q3 2011 Facilities available now CNH Bio-suite NanoToxicology Cell Imaging Tissue Engineering Molecular biology Microbiology Nano-suite Class 100/1000 ‘dirty’ clean room Bio-clean room Nanostructure growth SEM & AFM/SNOM NMR & Rheology Printing and Coating Direct access to: Clinical Trials Unit & Patient imaging (MRI&CT)

21. Centre for NanoHealth Swansea University www.nanohealth.swansea.ac.uk Projects challenges & opportunities

22. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Challenges & Opportunities Company recruitment Business development IP State Aid Managing stakeholder expectations Sustainability

23. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Company recruitment & Business development Project must offer real opportunities to businesses across Wales Take the project to the companies Launch Events/BioWales/KTNs etc Initial assistance is only the first step in the relationship Ensure multiple entries for engagement Pool of relevant expertise is essential Awareness of funding opportunities is essential Beware of ERDF overload – internal/institutional management vital

24. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Access Clinical/Biomedical/Engineering teams Fully integrated work flow Access at any stage Translational applications Great opportunities in a new area of healthcare CNH

25. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University IP / IPR IP policy of University has to be flexible Case by case consideration – one model DOES NOT fit all Primary consideration to companies – SHOW STOPPER Has to be managed differently to IP generated in house Early negotiation Companies understand and appreciate position of University State Aid compliance

26. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University State Aid Necessarily a major consideration under European law Documentation from WEFO offers clarity in their expectations Seek legal advice on wording used in business plans De minimus scheme easy to implement

27. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Sustainability – R&D pipeline Start early Awareness of all opportunities Development pipeline

28. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Delivery = Team work!! Medicine Engineering Finance Research and Innovation Procurement VC’s office ABMUHB External project managers / build team WEFO Early/Continued/Agreed/Managed engagement

29. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University CNH operational structure

30. Centre for NanoHealth Swansea University www.nanohealth.swansea.ac.uk NanoHealth R&D

31. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University

32. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Ultra-sensitive biosensor for the detection of bio-markers using bio-compatible ZnO nanowires. Diagnostics – Biosensors ZnO nanowires (AFM) Novel Materials Antibody Antigen Nanowire Electrode

33. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Surface topography. Material properties. Spatial resolution 5 - 20 nm. Cellular Analysis for Clinical Diagnostics

34. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Volume additive printing for the integration of biosensors with flexible polymer electronics, photonics and displays. Biosensors / Biomarker Detection

35. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Centre for NanoHealth

36. www.nanohealth.swansea.ac.uk Centre for NanoHealth Swansea University Centre for NanoHealth